Is Proin toxic?
While safe at therapeutic doses, when the chewable form is accidentally ingested in large amounts, it can result in severe poisoning. Clinical signs of high blood pressure, abnormal heart rate, dilated pupils, tremors, agitation, and even seizures can be seen. Prompt veterinary attention is required with any overdose.
Can humans take PROIN ER?
Keep PROIN ER in a secured location out of reach of dogs, cats, and other animals Not for human use. Keep out of reach of children. Consult a physician in case of accidental ingestion by humans.
Is Proin a controlled substance?
What is Proin? Proin is an aid in the management of urinary incontinence in dogs. Proin requires a prescription from your veterinarian, and is considered a controlled substance in some states.
Can Proin cause kidney problems?
Abnormal gait, seizures or tremors, as well as liver enzyme elevations, kidney failure, blood in urine and urine retention have been reported. In some cases, death, including euthanasia, has been reported.
Is Proin an estrogen?
The FDA had already approved Proin Chewable Tablets in 2011 (the same year they approved Incurin, an estrogen-based medication for canine urinary incontinence), which had to be administered two to three times a day.
Can Proin cause seizures?
Are there any potential side effects? The most common side effects include vomiting, diarrhea, lack of appetite, increased thirst, restlessness, irritability, and difficulty urinating. Serious side effects include seizures, collapse, or stroke-like signs (for example, not being able to walk).
Can humans take phenylpropanolamine hydrochloride?
Phenylpropanolamine has been found to increase the risk of hemorrhagic stroke (bleeding into the brain or into tissue surrounding the brain) in women. Men may also be at risk. Although the risk of hemorrhagic stroke is very low, FDA recommends that consumers not use any products that contain phenylpropanolamine.
How long does it take for Proin to start working?
Once it has been administered, urinary incontinence in dogs usually begins to improve in an hour or two. The medication typically remains in the body for four to seven hours. However, when you first start your dog’s regimen of Proin, it may take a few days before you see an effect on your dog’s incontinence.
Is there a generic for Proin?
Phenylpropanolamine (brand names: Proin®, Propalin®, Cystolamine®, Uricon®, Uriflex-PT®) is a sympathomimetic medication used to treat urinary incontinence due to poor muscle tone in the urethral sphincter. Its use in cats and dogs at certain doses to treat urinary incontinence is ‘off label’ or ‘extra label’.
Does Proin work immediately?
Does Proin cure incontinence?
Yes, you can give your dog Proin for control of urinary incontinence. Proin is an FDA-approved drug for dogs that cannot hold pee as a result of urethral sphincter hypotonus.
Can you overdose on Proin?
PROIN may cause increased thirst; therefore, provide ample fresh water. Overdose has been associated with dogs chewing through closed bottles of PROIN and consuming multiple tablets….Precautions.
| Adverse reactions | Total N=125 |
|---|---|
| Diarrhea | 6.4% |
| Lethargy | 5.7% |
| Anxiety/behavior change/aggression | 5.7% |
What was phenylpropanolamine used for in humans?
Phenylpropanolamine is an ingredient used in many over-the-counter (OTC) and prescription cough and cold medications as a decongestant and in OTC weight loss products.
Why phenylpropanolamine is banned?
Phenylpropanolamine has been taken off the market in the United States because of the increased risk of hemorrhagic stroke in women associated with its use as an appetite suppressant.
What happens when Proin stops working?
When Proin fails to work, especially in spayed female dogs, the use of low doses of prescription estrogen or Stilbestrol (as it is known as) or DES, can sometimes be quite helpful in managing urinary incontinence in conjunction with Proin or by itself.
What can I use instead of Proin?
Diethylstilbestrol (DES for short) is an alternative treatment method for canine urinary incontinence that is often administered for dogs that do not tolerate Proin well.
What is comparable to Proin?
Such herbs include uva ursi, horsetail, raspberry leaf, yarrow, marshmallow and plaintain. Consult with a certified herbalist or holistic veterinarian about customizing an herbal formula designed to correct a hormonal imbalance, if applicable.
Is Proin forever?
Dogs can stay on Proin for over 180 days without developing serious issues. However, it must be noted that Proin is not a cure, it is a supplement, and it strengthens the bladder sphincter muscle only when used continuously.
Can I cut Proin in half?
Administer PROIN ER with food (see Clinical Pharmacology). Do not split or crush tablets.
What kind of drug is Proin 25 mg?
Warnings and cautions for Proin Chewable Tablets (25 mg) Direction and dosage information for Proin Chewable Tablets (25 mg) PROIN Chewable Tablets are scored and contain the active ingredient phenylpropanolamine hydrochloride (PPA), USP, in three different strengths: 25 mg, 50 mg and 75 mg per tablet in a palatable formulation.
What is the molecular weight of Proin in HCl?
Description: PROIN (phenylpropanolamine hydrochloride) is a sympathomimetic amine closely related to ephedrine. Phenylpropanolamine hydrochloride (PPA) is the nonproprietary designation for benzenemethanol,α – (1-aminoethyl) – hydrochloride, (R*,S*) – , (± ). The empirical formula is C 9 H 13 NO• HCl and the molecular weight is 187.67.
How much Proin should I take for weight loss?
The total recommended dosage for oral administration is 2 mg/kg (0.91 mg/lb) of body weight twice daily. PROIN is scored and dosage should be calculated in half-tablet increments. Not for human use. Keep out of reach of children. Consult a physician in case of accidental ingestion by humans.
How much Proin can I give my Dog for incontinence?
PROIN is indicated for the control of urinary incontinence due to urethral sphincter hypotonus in dogs. The total recommended dosage for oral administration is 2 mg/kg (0.91 – mg/lb) of body weight twice daily. PROIN is scored and dosage should – be calculated in half-tablet increments.