What kind of drug is daratumumab?
Daratumumab is in a class of medications called monoclonal antibodies. It works by helping the body to slow or stop the growth of cancer cells.
What is daratumumab made from?
Daratumumab is an immunoglobulin G1 kappa (IgG1k) human mAb that binds to a unique CD38 epitope on CD38-expressing cells with high affinity and was developed by the immunization of human immunoglobulin transgenic mice with recombinant CD38 protein [16]. de Weers et al.
How long can you take daratumumab?
Official answer. Darzalex is administered until signs of progression of multiple myeloma (MM) occur, or side effects become intolerable. Treatment durations of up to 25 months have been reported in clinical trials (range 0.1 month to 40.44 months).
Is daratumumab a chemotherapy?
DARZALEX® (daratumumab) is a prescription medicine used to treat a type of blood cancer called multiple myeloma. DARZALEX® is not chemotherapy. It is a targeted monoclonal antibody that helps slow or stop the progression of multiple myeloma in several ways.
What is the success rate of daratumumab?
Daratumumab, Lenalidomide, and Dexamethasone The overall response rate was 81%, with 34% of patients achieving a complete response or better and 63% achieving a very good partial response (VGPR) or better.
Is daratumumab an immunotherapy?
Immunotherapy with monoclonal antibodies, such as daratumumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.
How good is daratumumab?
The overall response rate was 81%, with 34% of patients achieving a complete response or better and 63% achieving a very good partial response (VGPR) or better. The median response duration was not reached, and 91% of patients were free of disease progression at 12 months.
How much does daratumumab cost?
However, daratumumab is a costly drug, priced at nearly $6,500 per infusion; as a result, it is unclear whether it provides sufficient value in this clinical setting.
What is the treatment after daratumumab?
Daratumumab with bortezomib This starts as once a week but gets less often after a couple of months and is eventually given every 4 weeks. You also take dexamethasone (a steroid). You carry on having daratumumab until it stops working. You have bortezomib once or twice a week.
What is the cost of daratumumab?
How long do side effects of daratumumab last?
These effects may last up to 6 months after your last dose.
Which fruit is good for multiple myeloma?
Good sources of fiber include: Fruits like apples and pears. Dried fruits like figs and prunes. Whole grains.
Do you lose your hair with daratumumab?
Hair loss does not occur with daratumumab. Increased calcium in the blood may sometimes occur. To help prevent high calcium: • Keep active.