What is von Willebrand Type 2?
Disease definition. A form of von Willebrand disease (VWD) characterized by a bleeding disorder associated with a qualitative deficiency and functional anomalies of the Willebrand factor (VWF).
What are the levels of von Willebrand disease?
There are three major subtypes of von Willebrand disease, classified as partial quantitative deficiency (low levels) of von Willebrand factor (type 1), qualitative deficiency (type 2), or virtually complete deficiency (type 3).
What does VWD carrier mean?
Background. von Willebrand Disease (abbreviated vWD) is an inherited bleeding disorder caused by lack of von Willebrand factor protein (vWF). This protein circulates in the blood stream and must be present at the site of blood vessel injury in order to control bleeding from that vessel.
Does Von Willebrands get worse with age?
VWF levels increase with age and elevated levels are associated with an increased risk of venous thromboembolism and cardiovascular disease (CVD). Patients with von Willebrand disease (VWD) due to a deficiency or dysfunction of VWF may have symptoms that ameliorate with aging or may have exacerbation of their disease.
Is von Willebrand disease life threatening?
Complications. Rarely, von Willebrand disease can cause uncontrollable bleeding, which can be life-threatening. Other complications of von Willebrand disease can include: Anemia.
Can von Willebrand disease go away?
Von Willebrand disease can’t be cured. But with treatment and self-care, most people with this disease can lead active lives.
Can VWD skip a generation?
Autosomal dominant VWD is caused by changes in only one copy of the gene related to the disorder. In autosomal dominant inheritance, a child will inherit the bleeding disorder if he or she gets a VWD allele (the form of the gene that has a genetic change causing VWD) from one parent who has the disorder.