What is dengue virus nucleic acid?
Dengue Virus Genome and Structure The dengue virus genome is a single strand of RNA. It is referred to as positive-sense RNA because it can be directly translated into proteins. The viral genome encodes ten genes (Figure 2). The genome is translated as a single, long polypeptide and then cut into ten proteins.
How is flavivirus treated?
Most people become unwell within 3 to 11 days after being bitten by an infective mosquito. Treatment: There is no specific treatment for these infections.
Is Dengue a virus ssRNA?
The DENV genome is about 11000 bases of positive-sense, single stranded RNA (ssRNA) that codes for three structural proteins (capsid protein C, membrane protein M, envelope protein E) and seven nonstructural proteins (NS1, NS2a, NS2b, NS3, NS4a, NS4b, NS5).
Is there Dengue Vaccine?
One dengue vaccine has been licensed, Dengvaxia® (CYD-TDV), developed by Sanofi Pasteur. Approximately five additional dengue vaccine candidates are in clinical development, with two candidates (developed by NIH/Butantan and Takeda) now in Phase III trials.
What diseases are caused by Flavivirus?
Species of Flaviviridae are transmitted by either insects or arachnids and cause severe diseases such as yellow fever, dengue, tick-borne encephalitis, and Japanese B encephalitis.
What is causative agent of dengue?
Dengue is caused by a virus of the Flaviviridae family, Flavivirus genus which includes viruses such as yellow fever, West Nile and tick-borne encephalitis. There are four distinct dengue viruses without cross immunity.
How long do dengue antibodies last?
Serological methods. Serological methods, such as enzyme-linked immunosorbent assays (ELISA), may confirm the presence of a recent or past infection, with the detection of anti-dengue antibodies. IgM antibodies are detectable ~1 week after infection and remain detectable for about 3 months.
What kind of treatment is required for dengue fever?
No specific treatment for dengue fever exists. While recovering from dengue fever, drink plenty of fluids. Call your doctor right away if you have any of the following signs and symptoms of dehydration: Decreased urination.
What type of vaccine is Dengvaxia?
Sanofi Pasteur’s Dengvaxia (CYD-TDV) is a live attenuated tetravalent chimeric vaccine made using recombinant DNA technology by replacing the PrM (pre-membrane) and E (envelope) structural genes of yellow fever attenuated 17D strain vaccine with those from the four dengue serotypes.
Is dengue a flavivirus?
Dengue virus (DENV) belongs to the family Flaviviridae, genus Flavivirus. It is a single-stranded positive-sense ribonucleic acid virus with 10,700 bases. The genus Flavivirus includes other arthropod borne viruses such as yellow fever virus, West Nile virus, Zika virus, tick-borne encephalitis virus.
Is Dengue fever caused by flavivirus?
Dengue is caused by a virus of the Flaviviridae family and there are four distinct, but closely related, serotypes of the virus that cause dengue (DENV-1, DENV-2, DENV-3 and DENV-4). Recovery from infection is believed to provide lifelong immunity against that serotype.
What medicine could be given to dengue patients?
No treatment: No specific antiviral agents exist for dengue. Supportive care is advised: Patients should be advised to stay well hydrated and to avoid aspirin (acetylsalicylic acid), aspirin-containing drugs, and other nonsteroidal anti-inflammatory drugs (such as ibuprofen) because of their anticoagulant properties.
How long platelets drop dengue?
3. When do platelets decrease in dengue fever? Platelet counts usually drop significantly by day 4 of illness. In adults without dengue shock, platelet counts drop slightly to moderate from day 3 to day 7 of illness and return to normal by day 8 or 9.
How can we increase immunity in dengue?
Here is the list of foods which can strengthen your immunity and eliminate the risk of dengue fever….Dengue fever prevention: Immunity boosting foods
- Citrus foods. Citrus foods are rich in vitamin C which helps in building strong immunity.
- Garlic.
- Yogurt.
- Spinach.
- Almonds.
- Turmeric.
- Ginger.
Is NITD008 a potential adenosine analog for the treatment of DENV infection?
Neither a vaccine nor an antiviral therapy is currently available for prevention and treatment of DENV infection. Here, we report a previously undescribed adenosine analog, NITD008, that potently inhibits DENV both in vitro and in vivo.
Is castanospermine a potent inhibitor of dengue virus infection?
J Infect Dis 186:1165–1168. (2005) Castanospermine, a potent inhibitor of dengue virus infection in vitro and in vivo. J Virol 79:8698–8706. (2004) A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent pharmacokinetic properties.
What is the function of adenosine inhibitors in viral RNA synthesis?
Collectively, the results suggest that this adenosine inhibitor is phosphorylated to an active (triphosphate) form which functions as a chain terminator for viral RNA synthesis. Adenosine / chemistry Adenosine / metabolism
How do you reduce antiviral activity of (14)C-labeled drugs?
Suppression of host adenosine kinase, using a specific inhibitor (iodotubercidin) or small interfering RNA (siRNA), abolished or reduced the compound’s antiviral activity in cell culture. Studies of rats showed that (14)C-labeled compound was converted to mono-, di-, and triphosphate metabolites in vivo.