What are SMOF lipids?

Table of Contents

SMOFlipid is a composite parenteral nutrition (PN) lipid, comprised of soybean oil (30%), medium-chain triglycerides (MTCs, 30%), olive oil (25%), and fish oil (15%).

Why are fat emulsions given with TPN?

A lipid emulsion should usually be provided with PN to prevent depletion of essential fatty acids, lower the risk of hyperglycaemia, and prevent hepatic steatosis.

What is lipid emulsion therapy?

Lipid emulsion therapy is a medication used in the management and treatment of Local anesthetic toxicity. This activity reviews the indications, action, and contraindications for lipid emulsion therapy as a valuable agent in the management of local anesthetic toxicity.

What is the difference between SMOF and Intralipid?

Given the various oils in Smoflipid, the primary concern with dispensing this product instead of Intralipid is with patients who have an allergy to fish (which poses no problem with Intralipid). Also, unlike Intralipid, Smoflipid does not have a pediatric indication if dispensed in error to this population.

Why are SMOF lipids better?

Benefits of the blend. SMOFlipid showed lower concentrations of liver enzymes (ALT, AST) compared to soybean oil lipid emulsions, indicating an improvement in the patient’s liver function. Monitor liver function. If SMOFlipid-treated patients develop liver test abnormalities, consider discontinuation or dose reduction.

What is the composition of TPN?

TPN is a mixture of separate components which contain lipid emulsions, dextrose, amino acids, vitamins, electrolytes, minerals, and trace elements. [7][8] TPN composition should be adjusted to fulfill individual patients’ needs. The main three macronutrients are lipids emulsions, proteins, and dextrose.

Why do you need a filter for TPN?

In-line intravenous filters serve a critical purpose in reducing exposure to particulate matter during parenteral nutrition (PN) therapy. Particles greater than 2 microns, which are retained by 1.2 micron filters, appear to pose the most serious risk for adverse consequences.

Can you mix TPN and lipids?

Lipids may be administered as a separate infusion, before or after TPN, or may be given “piggy-back” into the tubing while the TPN is infusing. If the physician has ordered lipids to be given separately, follow the same procedures used to start and discontinue TPN.

What is Intralipid 20 used for?

INTRALIPID® 20% (20% i.v. fat emulsion) IS INDICATED AS A SOURCE OF CALORIES AND ESSENTIAL FATTY ACIDS FOR PATIENTS REQUIRING PARENTERAL NUTRITION FOR EXTENDED PERIODS OF TIME (USUALLY FOR MORE THAN 5 DAYS) AND AS A SOURCE OF ESSENTIAL FATTY ACIDS FOR PREVENTION OF EFAD.

Why lipid emulsion should be 30 or 20% not 10%?

The 20% lipid emulsion is favored rather than the 10% emulsion because of its better clearance as a result of its lower phospholipid content. Because lipid emulsions are derived from vegetable oils, they are also a natural source of variable amounts of vitamin K133 and vitamin E isomers.

What does SMOF stand for medical?

What is Intralipids IVF?

Intralipid or lipid emulsion, is an intravenous infusion that aims to provide essential fatty acids that are necessary for women who have suffered repeat miscarriages. It is normally given once or twice prior to the pregnancy and is prolonged by one dosage per month after the initial conception attempt.

Do SMOF lipids contain egg?

Each 100 mL of Smoflipid contains approximately 6 g soybean oil, 6 g MCT, 5 g olive oil, 3 g fish oil, 1.2 g egg phospholipids, 2.5 g glycerin, 16.3 to 22.5 mg all-rac-α-tocopherol, 0.3 g sodium oleate, water for injection, and sodium hydroxide for pH adjustment 3 (pH 6 to 9).

What is the difference between PN and TPN?

There are two primary types of PN, peripheral parenteral nutrition (PPN) and total parenteral nutrition (TPN). As the names imply, PPN is generally used for patients who need supplementary nutrition, while TPN is for patients who require all of their dietary needs replaced.

What are TPN additives?

TPN Electrolytes (multiple electrolyte additive) is a sterile, nonpyrogenic, concentrated solution of intra- and extracellular ions for intravenous infusion after dilution as a maintenance electrolyte replenisher…

What is the composition of clinoleic?

*Mixture of refined olive oil (approximately 80%) and refined soybean oil (approximately 20%) ClinOleic contains 47 milligrams or 1.5 mmol of phosphorus per 100 ml 3. Pharmaceutical form Emulsion for infusion. ClinOleic 20% contains 200 g/l of lipids corresponding to 200 mg/ml. 4. Clinical particulars

What is clinoleic emulsion used for?

The emulsion is for administration by intravenous infusion as part of a parenteral nutrition regimen. The posology depends on energy expenditure, the patient’s clinical status, body weight, and ability to metabolize ClinOleic 20%, as well as additional energy given orally/enterally.

What are the contraindications for clinoleic?

The use of ClinOleic is contra-indicated in the following situations: – hypersensitivity to egg protein, soya protein or peanut protein or to any of the active substances or excipients. – severe hyperlipidaemia and severe disorders of lipid metabolism characterised by hypertriglyceridemia.