What is the dosing for dexmedetomidine?
The usual dose of dexmedetomidine for procedural sedation is 1 mcg/ kg, followed by an infusion of 0.2 mcg/kg/h. Its onset of action is less than 5 min and the peak effect occurs within 15 min.
How do you give dexmedetomidine infusion?
Preparation of solutions is the same, whether for the loading dose or maintenance infusion. To prepare the infusion, withdraw 2 mL of Precedex Injection Concentrate, and add to 48 mL of 0.9% sodium chloride injection to a total of 50 mL. Shake gently to mix well.
What is dexmedetomidine used for?
Dexmedetomidine is used as an adjuvant for premedication, especially in patients susceptible to preoperative and perioperative stress because of its sedative, anxiolytic, analgesic, sympatholytic, and stable hemodynamic profile.
What is the difference between propofol and Precedex?
Precedex and propofol are different types of sedatives. Precedex is an alpha2-adrenergic agonist and propofol is a sedative-hypnotic.
How do you dilute a Dexdomitor?
Dexmedetomidine injection concentrate (100 mcg/mL) must be diluted in 0.9% sodium chloride solution to achieve the required concentration (4 mcg/mL) prior to administration. Add 2 mL (200 mcg) of dexmedetomidine to 48 mL of 0.9% sodium chloride for a total volume of 50 mL (4 mcg/mL).
Is dexmedetomidine compatible with dextrose?
Precedex has been shown to be compatible when administered with the following intravenous fluids: 0.9% sodium chloride in water. 5% dextrose in water.
Can you Bolus dexmedetomidine?
Justification Dexmedetomidine given in a single peri-operative bolus without subsequent infusion has been shown to be beneficial. It would be arguably more practical to administer the dose as a rapid bolus. The hemodynamic effects of this have not been previously studied in healthy ASA I-II children (aged 5-10 years).
What is another name for dexmedetomidine?
Dexmedetomidine, sold under the trade name Precedex among others, is a medication used for sedation. It is also used to treat acute agitation associated with schizophrenia or bipolar I or II disorder.
What class of drugs is dexmedetomidine?
Precedex belongs to a class of drugs called Sedatives.
Why is Precedex preferred over propofol?
Conclusions: For ICU patient sedation, dexmedetomidine may offer advantages over propofol in terms of decrease in the length of ICU stay and the risk of delirium. However, transient hypertension may occur when dexmedetomidine is administered with a loading dose or at high infusion rates.
Can you give propofol and Precedex together?
Using propofol together with dexmedetomidine may have increased effects on breathing, heart rate, blood pressure, and sedation. You will be monitored closely by your surgical team during anesthesia, and the doses of each medication adjusted accordingly.
What is the concentration of Dexdomitor?
Dexdomitor produces sedation and analgesia when administered intramuscularly (IM) at a dose of 500 mcg/m2, or intravenously (IV) at a dose of 375 mcg/m2.
What is the reversal agent for dexmedetomidine?
Atipamezole is a non-selective α2 adrenoceptor antagonist. It rapidly reverses sedation/analgesia induced by dexmedetomidine.
Is propofol compatible with Precedex?
Interactions between your drugs Using propofol together with dexmedetomidine may have increased effects on breathing, heart rate, blood pressure, and sedation. You will be monitored closely by your surgical team during anesthesia, and the doses of each medication adjusted accordingly.
Can you IV push precedex?
May be given undiluted by IV bolus. Precedex is a relatively selective alpha2-adrenergic agonist indicated for: -Sedation of initially intubated and mechanically ventilated patients during treatment in an intensive care setting. Administer Precedex by continuous infusion not to exceed 24 hours.
What is the most common side effect of dexmedetomidine?
Commonly reported side effects of dexmedetomidine include: bradycardia, hypotension, agitation, hypertension, nausea, and tachycardia. Other side effects include: vomiting, and xerostomia.
Can nurses give precedex?
Registered nurses must complete a moderate sedation inservice and maintain yearly competency. Sedation nurses may then administer midazolam, Fentanyl, Demerol and morphine, under the physician’s direction.
Can you take propofol and precedex together?
Can nurses give Precedex?
What is the generic name for Dexdomitor?
Dexmedetomidine, sold under the trade name Precedex among others, is a medication used for sedation.
How do you administer Dexdor?
Dexdor is given by infusion (drip) into a vein using a controlled infusion device. When Dexdor is used in intensive care, the dose is adjusted to achieve the desired level of sedation. If sedation with the maximum dose is not adequate, the patient can be switched to other medicines.
How much Dexdor should I take?
The amount of Dexdor depends on your age, size, general condition of health, the level of sedation needed and how you respond to the medicine. Your doctor may change your dose if needed and will monitor your heart and blood pressure during the treatment. Dexdor is diluted and it is given to you as an infusion (drip) into your veins.
What happens when Dexdor is used in intensive care?
When Dexdor is used in intensive care, the dose is adjusted to achieve the desired level of sedation. If sedation with the maximum dose is not adequate, the patient can be switched to other medicines.
Can Dexdor ® be used for ambulatory sedation?
Introduction: Dexdor ® do not include the possibility of loading dose, which could increase time to achieve adequate sedation for ambulatory procedures.