What antidepressants can cause rhabdomyolysis?
The use of sertraline and other SSRIs may be associated with development of rhabdomyolysis, especially in the presence of strenuous exercise.
Can Lexapro cause rhabdomyolysis?
There have been a small number of reported cases of escitalopram-related serotonin syndrome. Severe serotonin toxicity may induce muscular hyperactivity that can exceed 40°C/104°F, seizures or rhabdomyolysis.
How is citalopram metabolized?
Citalopram is metabolized mainly in the liver via N-demethylation to its main metabolite, demethylcitalopram by CYP2C19 and CYP3A4 7. Other metabolites include didemethylcitalopram via CYP2D6 metabolism, and citalopram N-oxide via monoamine oxidase enzymes and aldehyde oxidase.
Is escitalopram a metabolite of citalopram?
Escitalopram is the (S)-enantiomer of the racemic selective serotonin reuptake inhibitor antidepressant citalopram.
Can SSRI cause rhabdomyolysis?
Selective serotonin reuptake inhibitors (SSRIs) are associated with rhabdomyolysis. Sertraline is a known offender with at least 5 cases reported in literature. Most cases occurred within 4 months of drug initiation and after a dose increase or after a strenuous exercise.
Can serotonin cause rhabdomyolysis?
Serotonin syndrome can lead to rhabdomyolysis as ongoing severe rigidity leads to muscle breakdown due to overstimulation and overuse. Rhabdomyolysis in turn may lead to acute compartment syndrome via oedema and inflammation in skeletal muscles leading to increased local pressure and compromised blood flow.
What should you not take with citalopram?
Do not use citalopram with buspirone (Buspar®), fentanyl (Abstral®, Duragesic®), lithium (Eskalith®, Lithobid®), methylene blue injection, tryptophan, St John’s wort, amphetamines, or some pain or migraine medicines (eg, rizatriptan, sumatriptan, tramadol, Frova®, Imitrex®, Maxalt®, Relpax®, Ultram®, Zomig®).
How long before citalopram is out of my system?
As is the case with many other drugs, the body can retain remnants of the medication in hair follicles and urine long after it has been filtered out of the bloodstream. With Citalopram (Celexa), experts estimate that it can take up to 10-14 days for the drug to fully leave the body.
What drugs should not be taken with citalopram?
Which medications can cause rhabdomyolysis?
Which medications may cause rhabdomyolysis?
- Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors)
- Antihistamines (particularly in children)
- Salicylates.
- Caffeine.
- Fibric acid derivatives (eg, bezafibrate, clofibrate, fenofibrate, and gemfibrozil)
- Neuroleptics/antipsychotics.
What medications increase risk of rhabdomyolysis?
The higher the dose of statins, the higher the risk of rhabdomyolysis becomes. The risk also increases if certain drugs — including cyclosporine (Sandimmune) and gemfibrozil (Lopid) — are taken in combination with statins.
What are the long term side effects of citalopram?
To date, there are no known problems associated with long term use of citalopram. It is a safe and effective medication when used as directed.
Can I stay on citalopram for life?
Most people take citalopram for 6 months. But in some instances, a doctor may prescribe this substance for 9 months. Long-term use of antidepressants may put people at risk for type 2 diabetes, and SSRIs may cause heart rhythm abnormalities at higher doses.
Is 40mg of citalopram a lot?
Dosage and strength The usual dose of citalopram is 20mg a day for adults. But you might start at a lower dose and increase to a maximum dose of 40mg a day. If you are taking citalopram to prevent panic attacks, your starting dose will usually be 10mg once a day.
Can citalopram cause muscle pain?
you notice any of the following symptoms: trembling, muscle stiffness or spasm, slow movement, producing more saliva than usual or feeling restless. This affects less than 1 in every 100 people who take citalopram.
Do antidepressants affect life expectancy?
The analysis found that in the general population, those taking antidepressants had a 33 percent higher risk of dying prematurely than people who were not taking the drugs. Additionally, antidepressant users were 14 percent more likely to have an adverse cardiovascular event, such as a stroke or a heart attack.
Does sertraline cause rhabdomyolysis?
The patient’s rhabdomyolysis was attributed to sertraline in conjunction with recent exercise. Selective serotonin reuptake inhibitor (SSRI)-induced rhabdomyolysis has been documented in 5 case reports. Similar to most reports, our patient presented with rhabdomyolysis in the presence of both SSRI use and exercise.
What are the treatment options for rhabdomyolysis?
After treatment, physical therapy can help you strengthen your muscles after an initial period of rest. If the rhabdomyolysis is severe enough to cause kidney damage, you may need dialysis. Dialysis extracts (removes) some of your blood, takes out toxins, and returns the filtered blood. What are the side effects of the treatment for rhabdomyolysis?
What are the signs and symptoms of rhabdomyolysis?
The main signs of rhabdomyolysis include: Muscle swelling. Weak, tender and sore muscles. Dark urine that is brown, red or tea-colored. Some people also experience dehydration or decreased urination, nausea, or loss of consciousness.
How long does it take for rhabdomyolysis to develop?
Symptoms usually develop one to three days after the muscle injury, though some people may not even notice muscle soreness. The main signs of rhabdomyolysis include: