What are the indications for dobutamine?
Dobutamine is indicated in all paediatric age groups (from neonates to 18 years of age) as inotropic support in low cardiac output hypoperfusion states resulting from decompensated heart failure, following cardiac surgery, cardiomyopathies and in cardiogenic or septic shock.”
What is dobutamine used to treat?
Dobutamine stimulates heart muscle and improves blood flow by helping the heart pump better. Dobutamine is used short-term to treat cardiac decompensation due to weakened heart muscle.
What is the action of dobutamine?
In clinical use, dobutamine has a rapid onset of action and a short half-life. It increases myocardial contractility, while the reflex reduction in sympathetic tone, in response to augmentation of stroke volume, leads to a decrease in total peripheral resistance.
Why is dobutamine used for shock?
In septic shock, dobutamine is typically used to increase cardiac output and oxygen transport. Since dobutamine has a thermogenic effect,(14) it has also been used to evaluate the metabolic state of critically ill patients-the so-called dobutamine oxygen flux test.
What are the contraindications of dobutamine?
The medication is contraindicated in patients with acute myocardial infarction, unstable angina, left main stem disease, severe hypertension, arrhythmias, acute myocarditis or pericarditis, hypokalemia and idiopathic hypertrophic sub-aortic stenosis.
Is dobutamine used for hypotension?
Dobutamine and dopamine are catecholamines used to treat low blood pressure (hypotension), low cardiac output, and reduced perfusion of body organs due to shock, trauma, and sepsis.
Does dobutamine lower BP?
Hypotension. Precipitous decreases in blood pressure have occasionally been described in association with dobutamine therapy. Decreasing the dose or discontinuing the infusion typically results in rapid return of blood pressure to baseline values.
Is dobutamine used for hypertension?
Continuous intravenous inotropic dobutamine support can reasonably be given in the short term for hospitalized patients with severe systolic dysfunction who present with low blood pressure and a significantly decreased cardiac output to preserve systemic blood flow and protect from end-organ damage.
How does dobutamine help heart failure?
Dobutamine is a cardiac inotrope useful in the acute treatment of congestive heart failure. Dobutamine improves cardiac output, decreases pulmonary wedge pressure, and decreases total systemic vascular resistance with little effect on heart rate or systemic arterial pressure.
Why dobutamine is preferred over dopamine in heart failure?
Dobutamine produced a distinct increase in cardiac index, while lowering left ventricular end-diastolic pressure and leaving mean aortic pressure unchanged. Dopamine also significantly improved cardiac index, but at the expense of a greater increase in heart rate than occurred with dobutamine.
When do you use dobutamine instead of dopamine?
Unlike dopamine, dobutamine does not have any effect on the α2‐adrenergic receptors. Dobutamine is preferred when there is a need to improve low cardiac output. Dobutamine should be avoided in patients affected by outflow obstructions, pulmonic stenosis, or hypertrophic obstructive cardiomyopathy.
Why dobutamine is preferred over dopamine in CHF?
Dopamine was ineffective in lowering left ventricular end-diastolic pressure, but increased mean aortic pressure. We conclude that dobutamine is an effective, positive inotropic agent in patients with severe congestive heart failure.
Why is dobutamine used in acute heart failure?
How does dobutamine increase cardiac output?
Clinically, dobutamine increases cardiac output by selectively augmenting stroke volume, and this is associated with a decrease in total peripheral vascular resistance that is mediated, in part, by reflex withdrawal of sympathetic tone to the vasculature.
What is the indication of dobutamine injection?
INDICATIONS. Dobutamine injection is indicated when parenteral therapy is necessary for inotropic support in the short-term treatment of adults with cardiac decompensation due to depressed contractility resulting either from organic heart disease or from cardiac surgical procedures.
When is dobutamine used to treat cardiac decompensation?
Clinical particulars Dobutamine is indicated for patients who require a positive inotropic support in the treatment of cardiac decompensation due to depressed contractility.
What is the infusion rate for dobutamine?
Alternatively the infusion rate of dobutamine may be increased to 50 µg/kg/min. The experience in children and adolescents is limited to the treatment of patients requiring positive inotropic support. Only for intravenous infusion (syringe pump). Dilution is not required.
What is the composition of dobutamine hydrochloride?
1. Name of the medicinal product 2. Qualitative and quantitative composition Each ampoule/vial Dobutamine contains dobutamine hydrochloride corresponding to 250 mg dobutamine. 1 ml contains 5 mg dobutamine. Excipient with known effect: This medicine contains less than 1mmol sodium (23 mg) per 1 ml, that is to say essentially `sodium-free´.