How do you administer Cerezyme?
Cerezyme is administered as an intravenous infusion 1
- The recommended dosage of Cerezyme based upon disease severity ranges from 2.5 units/kg 3 times a week to 60 units/kg once every 2 weeks.
- For patients weighing 18 kg and greater, infuse the diluted Cerezyme solution over 1 to 2 hours.
What is Cerezyme used for?
Imiglucerase is used to treat a certain rare genetic problem (Gaucher disease). Imiglucerase replaces a certain natural substance (an enzyme called glucocerebrosidase) that is missing in people with Gaucher disease. This medication improves blood, bone, liver, and spleen problems caused by Gaucher disease.
Where is Cerezyme manufactured?
Cerezyme was one of the drugs manufactured at Genzyme’s Allston, Massachusetts plant, for which production was disrupted in 2009 after contamination with Vesivirus 2017.
How much does Cerezyme cost?
The cost for Cerezyme intravenous powder for injection 400 units is around $1,817 for a supply of 1 powder for injection, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
Is Cerezyme a biologic?
Cerezyme is a biologic therapy that is indicated to treat: pediatric and adult patients with a confirmed diagnosis of Type 1 Gaucher disease that results in one or more of the following conditions: anemia. thrombocytopenia. bone disease.
How is Cerezyme made?
Cerezyme® is produced by recombinant DNA technology using mammalian cell culture (Chinese hamster ovary). Purified imiglucerase is a monomeric glycoprotein of 497 amino acids, containing 4 N-linked glycosylation sites (Mr = 60,430).
How often is enzyme replacement therapy done?
Patients typically need an ERT infusion every 2 weeks, depending on the individual. You can receive ERT at an infusion center, a Gaucher disease treatment center or at home, and each setting has benefits and drawbacks.
What organs does Gaucher disease affect?
It is a disorder passed from parents to children (inherited). It causes fatty substances called lipids to build up in certain organs such as the spleen and liver. Organs can become very large and not work well. It can also affect the lungs, brain, eyes, and bones.
What diseases are caused by enzyme deficiency?
Examples include:
- Familial hypercholesterolemia.
- Gaucher disease.
- Hunter syndrome.
- Krabbe disease.
- Maple syrup urine disease.
- Metachromatic leukodystrophy.
- Mitochondrial encephalopathy, lactic acidosis, stroke-like episodes (MELAS)
- Niemann-Pick.
How often do you give imiglucerase?
Cerezyme® (imiglucerase for injection) is administered by intravenous infusion over 1-2 hours. Dosage should be individualized to each patient. Initial dosages range from 2.5 U/kg of body weight 3 times a week to 60 U/kg once every 2 weeks.
How do you administer imiglucerase?
Cerezyme® (imiglucerase for injection) is administered by intravenous infusion over 1-2 hours. Dosage should be individualized to each patient. Initial dosages range from 2.5 U/kg of body weight 3 times a week to 60 U/kg once every 2 weeks. 60 U/kg every 2 weeks is the dosage for which the most data are available.
What is the concentration of imiglucerase in USP?
After reconstitution with Sterile Water for Injection, USP, the imiglucerase concentration is 40 U/mL (see DOSAGE AND ADMINISTRATION for final concentrations and volumes). Reconstituted solutions have a pH of approximately 6.1.
What is imiglucerase?
Imiglucerase is a man-made form of an enzyme that occurs naturally in the body. It is used as an enzyme replacement in people with Type I Gaucher disease.