What is acetylcysteine the antidote for?
N-acetylcysteine (NAC), a GSH precursor, is the only currently approved antidote for an acetaminophen overdose. Unfortunately, fairly high doses and longer treatment times are required due to its poor bioavailability. In addition, oral and I.V. administration of NAC in a hospital setting are laborious and costly.
What drugs does acetylcysteine interact with?
Acetylcysteine has no known serious interactions with other drugs….Mild interactions of acetylcysteine include:
- azithromycin.
- bazedoxifene/conjugated estrogens.
- chloramphenicol.
- clarithromycin.
- demeclocycline.
- dichlorphenamide.
- doxycycline.
- erythromycin base.
Do side effects of NAC go away?
Side effects not requiring immediate medical attention Some side effects of acetylcysteine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine.
Which of the following is an indication for the use of acetylcysteine?
Acetylcysteine is indicated for mucolytic therapy and in the management of acetaminophen overdose.
What should not be taken with NAC?
Treatment with NAC may strengthen the effects of some medications that suppress the immune system, such as azathioprine (Imuran), cyclophosphamide (Cytoxan), or prednisone (Deltasone). Do not take NAC with these medications without talking to your doctor first.
How long does it take for NAC to leave your system?
NAC may only stay in the system for about 8-10 hours.
Can you overdose on acetylcysteine?
Some studies reported that administration of NAC 63.6% and even 50% is associated with mild to life-threateningly severe side effects; these are quite prevalent when using oral treatment, and there is always a risk of iatrogenic overdose when using intravenous NAC.
What is contraindicated with NAC?
Intravenous acetylcysteine is contraindicated in patients who have had a previous anaphylactoid reaction to acetylcysteine, and acetylcysteine solution for oral use or inhalation is contraindicated in patients who have had any type of hypersensitivity reaction to the drug.
What is the primary indication for acetylcysteine?
Acetylcysteine is indicated for mucolytic therapy and in the management of acetaminophen overdose. Build, train, & validate predictive machine-learning models with structured datasets. Acetylcysteine is indicated for mucolytic therapy and in the management of acetaminophen overdose.
How does acetylcysteine treat paracetamol overdose?
The antidote for acetaminophen poisoning, NAC, is theorized to work through a number of protective mechanisms. Since NAC is a precursor of glutathione, it increases the concentration of glutathione available for the conjugation of NAPQI.
Can you take NAC with magnesium?
No interactions were found between magnesium oxide and NAC. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Can you overdose on NAC?
How long does it take for NAC to get out of your system?
The half-life of NAC is approximately 5.6 hours, and 30 percent of the drug is renally excreted. With regard to side effects, oral or inhaled NAC has been associated with drowsiness, stomatitis, clamminess, rhinorrhea, and hemoptysis.
When should NAC be discontinued?
If APAP is undetectable and transaminase levels are normal, NAC can be discontinued at the end of the regime. If there is a detectable APAP level or AST is still elevated, restarting NAC at 6.25 mg/kg per hour (for IV protocol) or 70 mg/kg every four hours (for oral protocol) is the proper course.
What drug class is acetylcysteine?
It is avaiable in generic form under the name Acetylcysteine Solution. Mucomyst is a prescription medicine used to treat the symptoms of pulmonary disease and diagnostic bronchoscopy. Mucomyst may be used alone or with other medications. Mucomyst belongs to a class of drugs called Pulmonary, Other.
What are the side effects of acetylcysteine?
For Healthcare Professionals. Applies to acetylcysteine: compounding powder, inhalation solution, intravenous solution, oral capsule, oral tablet, oral tablet effervescent. The most common adverse events were anaphylactoid reaction, nausea, vomiting, flushing, and skin rash.
Can acetylcysteine be used as an antidote for acetaminophen?
Not all forms of acetylcysteine are effective as an acetaminophen antidote. Do not attempt to treat an acetaminophen overdose without medical advice. Acetylcysteine may also be used for purposes not listed in this medication guide. In an emergency, you may not be able to tell caregivers about your health conditions.
Does acetylcysteine interact with other medications or foods?
Acetylcysteine has no known severe interactions with other drugs. Acetylcysteine has no known serious interactions with other drugs. Moderate interactions of acetylcysteine include: This information does not contain all possible interactions or adverse effects.
What is acetylcysteine solution?
Acetylcysteine solution may also be used as an antidote for acetaminophen toxicity. Acetylcysteine is available under the following different brand names: N-acetylcysteine, and Mucomyst. Dosages of Acetylcysteine: