What is Plasmablastic myeloma?
Plasmablastic myeloma is a subtype of MM in which ≥2% of the clonal plasma cells are morphologically plasmablasts (6). It is a very rare and aggressive MM subtype, seen in about 5-10% of patients with MM and associated with an overall poor prognosis and survival (6, 7).
What abnormal cell morphology would you see in multiple myeloma?
Multiple myeloma is characterized by abnormalities in plasma cells, a type of white blood cell. These abnormal cells multiply out of control, increasing from about one percent of cells in the bone marrow to the majority of bone marrow cells.
What is Plasmablastic leukemia?
Abstract. Plasmablastic lymphoma (PBL) is an aggressive malignancy that usually occurs in the setting of immunosuppression. The immunohistochemical profile of PBL is that of terminally differentiated B lymphocytes. CD138, CD38, and MUM1 are usually immunopositive.
What is Plasmablastic lymphoma?
Plasmablastic lymphoma (PBL) is an aggressive lymphoma commonly associated with HIV infection. However, PBL can also be seen in patients with other immunodeficiencies as well as in immunocompetent individuals.
What is plasmablastic morphology?
Plasmablastic morphology was considered to be present (plasmablastic myeloma) when 2% or more plasmablasts were present in the plasma-cell population. Results: Patients underwent transplantation 5 to 88 months (median, 20 months) after the initial diagnosis of myeloma.
What is the survival rate of Plasmablastic lymphoma?
The prognosis is usually dismal for patients with PBL, with median overall survival ranging from 3 to 5 months. HIV-positive patients have a decreased overall survival compared to their HIV-negative counterparts.
How do you get Plasmablastic lymphoma?
The exact underlying cause of Plasmablastic lymphoma is poorly understood; however, it is often associated with suppression of the immune system (i.e. HIV infection, immunosuppressive therapy).
Is Plasmablastic lymphoma non-Hodgkin?
Plasmablastic lymphoma (PBL) is an aggressive B-cell malignancy that highly correlated with human immunodeficiency virus (HIV). Recently, PBL is also identified as a subtype of non-Hodgkin lymphoma (NHL), and it is estimated incidence of PBL accounts for approximately 5% of all HIV-positive NHL cases.
Why is it called plasma blast?
In immunology, a “plasmablast” refers to a short-lived differentiation stage between a post germinal centre B-cell and a mature plasma cell. Plasmablasts retain a proliferative capability together with an almost fully mature plasma cell phenotype [1].
What is plasma sarcoma?
Solitary bone plasmacytoma is a bone tumor that arises from plasma cells. Plasmacytomas can occur in any bone, but they are most common in the spine. At the Spine Hospital at the Neurological Institute of New York, we specialize in spinal plasmacytomas.
Can Plasmablastic lymphoma be cured?
Plasmablastic Lymphoma Is Curable The HAART Era. A 10 Year Retrospective By The AIDS Malignancy Consortium (AMC) | Blood | American Society of Hematology.
What is Plasmablastic morphology?
What is the normal percentage of plasma cells in bone marrow?
Normally, plasma cells make up about 2%–3% of the cells in bone marrow. In people with multiple myeloma, abnormal plasma cells make up at least 10% of the cells in the bone marrow.
Is plasma cell myeloma the same as multiple myeloma?
A type of cancer that begins in plasma cells (white blood cells that produce antibodies). Also called Kahler disease, multiple myeloma, and myelomatosis.
Is plasma cell myeloma curable?
There’s no cure, but treatments can slow its spread and sometimes make symptoms go away. A type of white blood cell called a plasma cell makes antibodies that fight infections in your body.
What is plasmablastic myeloma (PBM)?
Plasmablastic myeloma (PBM) is a rare morphological variant of plasma cell neoplasm which is also known to be extremely aggressive with poor survival [3]. Both these malignancies have overlapping clinical and pathological features which pose a diagnostic dilemma [4].
Is plasmablastic lymphoma the same as plasma cell myeloma?
Plasmablastic lymphomas and plasmablastic plasma cell myelomas have nearly identical immunophenotypic profiles Plasmablastic lymphoma is an aggressive neoplasm that shares many cytomorphologic and immunophenotypic features with plasmablastic plasma cell myeloma.
What is the prevalence of plasmablastic morphology in multiple myeloma?
The prevalence of plasmablastic morphology in patients with newly diagnosed myeloma is approximately 10%. Many of the previous western studies have shown that plasmablastic cytomorphologic features of the neoplastic plasma cells in marrow aspirate strongly correlate with poor survival.
What is plasmablastic lymphoma and how is it diagnosed?
Plasmablastic lymphomas and plasmablastic myelomas are malignancies with overlapping clinical and pathological features which pose a diagnostic dilemma and are known to be aggressive with a poor outcome. CD38 is a common immunophenotypic maker for both these malignancies and provides a rationale for using daratumumab-based regimes.