What is Gastroretentive drug delivery system Slideshare?
Gastroretentive drug delivery is an approach to prolong gastric residence time, there by targeting site-specific drugs release in the upper gastrointestinal tract (GIT) for local or systemic effects. It is obtained by retaining dosage form into stomach and by releasing the in controlled manner.
Which evaluation test is used in Gastroretentive drug delivery system?
Buoyancy lag time test was performed to check the floating behavior. The tablets were dropped in the dissolution medium, i.e., 0.1 N HCl and the time taken by them to come to the surface of the dissolution medium, i.e., time taken for floating on surface was reported.
What is mucoadhesive drug delivery system?
Mucoadhesive drug delivery systems prolong the residence time of the dosage form at the site of application or absorption. They facilitate an intimate contact of the dosage form with the underlying absorption surface and thus improve the therapeutic performance of the drug.
What are the components of Tdds?
Polymer matrix, drug, permeation enhancers are the main components of TDDS; Polymers include gelatine, gum Arabic, methyl cellulose, starch, shellac, etc. (as a natural) to synthetic ones (polyethylene, polystyrene, acetyl co-polymer, polyvinyl chloride, polyamide, polyvinyl acetate, etc.)
What is full form of Grdds?
Gastro retentive drug delivery system (GRDDS)
What is the primary barrier for transdermal drug delivery system?
The first-generation approach to transdermal delivery is limited primarily by the barrier posed by skin’s outermost layer called stratum corneum, which is 10 to 20 µm thick (Fig. 2). Underneath this layer is the viable epidermis, which measures 50 to 100 µm and is avascular.
What is the characteristics of mucoadhesive system?
What is the characteristics of mucoadhesive systems? Explanation: Bio adhesive polymers when they are used as a cross linked polyacrilic acid and are incorporated in a tablet, it allows it to adhere to the gastric mucosa or epithelium.
What is the advantage of mucoadhesive drug delivery system?
Mucoadhesive drug delivery gives rapid absorption and good bioavailability due to its considerable surface area and high blood flow. Drug delivery across the mucosa bypasses the first-pass hepatic metabolism and avoiding the degradation of gastrointestinal enzymes.
What are the types of Tdds?
TDDS classified into three types 1. Reservoir system 2. Matrix system 3. Microresevior system.
What are the characteristics of the reservoir or membrane Tdds devices?
The polymers employed for matrix system may be hydrophilic or lipophilic. 5. What are the characteristics of the reservoir or membrane devices? Explanation: These devices are used when the drug permeation through the stratum corneum is rapid than the rate of drug diffusion from the device.
Why do we need Grdds?
GRDDS are feasible for drugs that have low absorption in the lower part of the GIT, are unstable and poorly soluble at alkaline pH, have a short half-life, and show local activity at the upper part of the intestine for eradication of Helicobacter pylori [3,4,5,6,7,8,9,10,11,12,13,14,15].
What is the approach of Grdds?
2. These approaches of GRDDS help in delivering the medicament in a sustained and restrained way through the gastrointestinal tract. Classification of GRDDS: Gastroretentive drug delivery system is classified into mainly two types floating and non- floating systems.
What is the characteristic of mucoadhesive drug delivery system Mcq?
How mucoadhesive bond is formed?
The mucoadhesive joint formation mainly involves two mechanisms: adhesion by hydration due to water attraction from mucus gel layer [31–33], and chemical bonds formation, in particular hydrogen bonds and ionic interactions between the positively charged amino groups of the polymer and the negatively charged moieties of …
What is difference between mucoadhesive and bioadhesive?
Leung and Robinson[3] described mucoadhesion as the interaction between a mucin surface and a synthetic or natural polymer. Mucoadhesion should not be confused with bioadhesion; in bioadhesion, the polymer is attached to the biological membrane and if the substrate is mucus membrane the term mucoadhesion is used.
What are mucoadhesive DDS applications?
Over the years, mucoadhesive and bioadhesive systems have been used for nasal, ocular, buccal, vaginal, rectal and oral drug delivery. In early studies of mucoadhesion, different methods were developed or modified from other areas of adhesion research.
What is gastro-retentive delivery?
5. Gastro-retentive delivery is one of the site specific delivery of the drugs at stomach. It is obtained by retaining dosage form into stomach and drug is being released at sustained manner to specific site either in stomach or intestine. 6. Differ from Conventional Release…
What is the role of gastric transit in oral drug delivery system?
Introduction Conventional oral drug delivery system (DDS) is complicated by limited gastric residence time (GRT). Rapid GI transit can prevent complete drug release in absorption zone & reduce the efficacy of the administered dose since the majority of drugs are absorbed in stomach or the upper part of small intestine.
What is a gastro retentive drug delivery system?
Commercial Gastroretentive Formulation 32. Conclusion Gastro retentive drug delivery systems are the most preferable systems in order to deliver the drugs which have a narrow absorption window near the gastric region. Now a days a number of drug delivery devices are being developed which aim at releasing the drug at gastric region.
What is the role of the stomach in drug delivery?
After oral administration, such a drug delivery would be retained in the stomach and release the drug in a controlled manner, so that the drug could be supplied continuously to its absorption sites in the gastrointestinal tract (GIT) [1].