What is the pathophysiology of interstitial lung disease?
General pathophysiology of ILD Wound healing and fibrosis are complex, involving numerous cellular processes and molecular pathways (eg, cell adhesion, migration, proliferation, apoptosis, extracellular matrix (ECM) biology, and phenotypic reprogramming).
What is meant by interstitial pneumonia?
Sept. 12, 2018. The interstitial pneumonias (IPs) are a heterogeneous group of diffuse parenchymal lung diseases characterized by specific clinical, radiologic and pathologic features.
How does interstitial pneumonia occur?
Interstitial lung disease can be caused by long-term exposure to hazardous materials, such as asbestos. Some types of autoimmune diseases, such as rheumatoid arthritis, also can cause interstitial lung disease. In some cases, however, the causes remain unknown. Once lung scarring occurs, it’s generally irreversible.
What is the pathophysiology of pulmonary fibrosis?
Currently, pulmonary fibrosis is regarded as a disease caused by repeated subclinical injury leading to epithelial damage and subsequent destruction of the alveolar-capillary basement membrane. This process initiates the infiltration of fibrotic cells and the activation of (myo)fibroblasts.
What does the medical term interstitial mean?
Medical Definition of interstitial 1 : situated within but not restricted to or characteristic of a particular organ or tissue —used especially of fibrous tissue. 2 : affecting the interstitial tissues of an organ or part interstitial hepatitis.
What is interstitial pneumonia with autoimmune features?
Interstitial pneumonia with autoimmune features (IPAF) is a term to describe individuals with both interstitial lung disease (ILD) and combinations of other clinical, serologic, and/or pulmonary morphologic features, which presumably originate from an underlying systemic autoimmune condition, but do not meet current …
What is interstitial pulmonary fibrosis?
Interstitial lung disease refers to a group of about 100 chronic lung disorders characterized by inflammation and scarring that make it hard for the lungs to get enough oxygen. The scarring is called pulmonary fibrosis. The symptoms and course of these diseases may vary from person to person.
What is emphysema pathophysiology?
Emphysema is pathologically defined as an abnormal permanent enlargement of air spaces distal to the terminal bronchioles, accompanied by the destruction of alveolar walls and without obvious fibrosis.
What does interstitial mean in biology?
in·ter·sti·tial adj. 1. Relating to, occurring in, or affecting interstices. 2. Anatomy Relating to or situated in the small, narrow spaces between tissues or parts of an organ: interstitial cells; interstitial fluid.
What is another name for interstitial?
Interstitial synonyms In this page you can discover 6 synonyms, antonyms, idiomatic expressions, and related words for interstitial, like: interspatial, substitutional, invagination, perivascular, eosinophilic and subendothelial.
Is interstitial lung disease an autoimmune disease?
Interstitial lung disease (ILD) refers to a broad category of conditions that produce inflammation and scarring in the lungs. Autoimmune ILD is caused specifically by autoimmune disorders, which involve the body’s own immune system attacking the lungs.
How would you distinguish between ARDS and acute interstitial pneumonia?
Cases that meet clinical and pathologic criteria for AIP overlap substantially with those that fulfill clinical criteria for ARDS. The main differences between AIP and ARDS are that AIP requires a histologic diagnosis of DAD and exclusion of known etiologies.
Can pneumonia cause interstitial lung disease?
Cryptogenic organizing pneumonia: Interstitial lung disease that can resemble pneumonia without an infection being present. Acute interstitial pneumonitis: Sudden damage to the interstitium that is severe and often requires emergency medical treatment and life-support.
What is interstitial lung disease Quizlet?
Interstitial lung disease. Print. Interstitial (in-tur-STISH-ul) lung disease describes a large group of disorders, most of which cause progressive scarring of lung tissue. The scarring associated with interstitial lung disease eventually affects your ability to breathe and get enough oxygen into your bloodstream.
What is acute interstitial pneumonia?
Acute interstitial pneumonia (AIP – also known as Hamman-Rich syndrome) is an acute, rapidly progressive idiopathic pulmonary disease that often leads to fulminant respiratory failure and acute respiratory distress syndrome (ARDS).[1]
What is interstitial lung disease (diffused parenchymal diseases)?
Interstitial lung disease (diffused parenchymal diseases) are a heterogeneous group of disorders characterized by fibrosis (scarring) of the lungs. These are classified on the basis of histopathological, radiologic and clinical parameters.
What are the symptoms of interstitial lung disease?
Lung transplant is an option for some people who have interstitial lung disease. The primary signs and symptoms of interstitial lung disease are: Shortness of breath at rest or aggravated by exertion By the time symptoms appear, irreversible lung damage has often already occurred.