What is the pathophysiology of osteoporosis?
Pathophysiology of osteoporosis Osteoporosis is a classical age-related disease that affects women more often than men. The hypothesis that osteoporosis is a consequence of estrogen deficiency, has been proposed as early as 1941 by Albright and colleagues. The exact mechanisms of this steroid hormone deficiency in postmenopausal w …
Is osteoporosis caused by estrogen deficiency?
Osteoporosis is a classical age-related disease that affects women more often than men. The hypothesis that osteoporosis is a consequence of estrogen deficiency, has been proposed as early as 1941 by Albright and colleagues. The exact mechanisms of this steroid hormone deficiency in postmenopausal w …
Is S1P involved in the pathophysiology of osteoporosis?
As the global elderly population increases, the incidence of osteoporosis will greatly increase, and the associated adverse consequences will become more serious. S1P plays an important role in homeostasis, and disruption of the balance between osteoblasts and osteoclasts may induce osteoporosis.
Who are the authors of osteoporosis?
Osteoporosis: Pathophysiology and therapeutic options Ursula Föger-Samwald,*,1Peter Dovjak,2Ursula Azizi-Semrad,3Katharina Kerschan-Schindl,4and Peter Pietschmann1 Ursula Föger-Samwald
Osteoporosis is a disease that is characterized by low bone mass, deterioration of bone tissue, and disruption of bone microarchitecture: it can lead to compromised bone strength and an increase in the risk of fractures (1). Osteoporosis is the most common bone disease in humans, representing a major public health problem.
What is the relationship between osteoporosis and estrogen deficiency?
The majority of postmenopausal women with osteoporosis have bone loss related to estrogen deficiency. The rapid bone loss results from an increase in bone turnover with an imbalance between bone resorption and bone formation.
What is the relationship between osteoporosis and glucocorticoids?
The majority of postmenopausal females with osteoporosis have bone loss related to estrogen deficiency. The rapid bone loss results from an increase in bone turnover with an imbalance between bone resorption and bone formation. Glucocorticoids are the most widely used anti-inflammatory drug around the world.
Is osteoporosis a serious health issue among aging postmenopausal women?
This article has been cited by other articles in PMC. Osteoporosis is a serious health issue among aging postmenopausal women. The majority of postmenopausal women with osteoporosis have bone loss related to estrogen deficiency.