Which is better simvastatin or Lipitor?
No strong head-to-head trials comparing atorvastatin and simvastatin have been conducted. However, atorvastatin is considered a more potent drug than simvastatin. In one recent comparative study, atorvastatin was found to be more effective at lowering LDL cholesterol (LDL-C) than simvastatin.
Is there a difference between atorvastatin and simvastatin?
Dose for dose, atorvastatin is more potent than simvastatin at blocking the target enzyme, HMGCoA; this effect is overcome by using a higher dose of simvastatin. In controlled dosing studies, simvastatin 40 mg and atorvastatin 10 mg and 20 mg are equally effective.
Why was Lipitor taken off the market?
A recall occurs when a product is removed from the market due to a potentially harmful defect. Pfizer voluntarily recalled specific bottles of Lipitor (40 mg only) due to reports of an unusual odor.
Is Lipitor the same as simvastatin?
Simvastatin (Zocor) and atorvastatin (Lipitor) are two types of statins that your doctor may prescribe for you. Statins are often prescribed to help lower your cholesterol. According to the American College of Cardiology, statins can help if you: have a buildup of cholesterol in your blood vessels.
Can you switch from atorvastatin to simvastatin?
A large proportion of patients who switch from atorvastatin to simvastatin are prescribed doses that are not therapeutically equivalent, and these patients were significantly less likely to meet LDL-C treatment goals compared with patients who remained on atorvastatin.
What is the safest statin on the market?
Simvastatin and pravastatin had the best safety profile, according to this review. Overall, the researchers found a 9 percent increased risk of type 2 diabetes in people taking statins.
Is simvastatin still on the market?
This drug has been on the market for 20 years. And, despite the tone of much of the coverage, this is not a medicine only taken by a few people….Simvastatin Snapshot.
| Simvastatin Snapshot | |
|---|---|
| Vytorin, all doses | 8.6 m |
| Vytorin, 80mg | 1.3 m |
| Simcor, all doses | 0.94 m |
| Simcor, 80mg | 0.18 m |
What is the safest statin?
Is it okay to switch from atorvastatin to simvastatin?
Which statin is best?
A systematic review of 75 clinical trials found that rosuvastatin and atorvastatin were the only statins that lowered LDL cholesterol by more than 40% (hence, they’re the only “high-intensity” statins).
Is 10 mg of Lipitor enough?
The typical dosage range of Lipitor is 10 mg to 80 mg taken once per day. The normal starting dosage is 10 mg to 20 mg taken once per day. But if you have very high cholesterol, your doctor may have you start with a dosage of 40 mg taken once per day.
What is the mildest statin drug?
In the analysis of 135 previous studies, which included nearly 250,000 people combined, researchers found that the drugs simvastatin (Zocor) and pravastatin (Pravachol) had the fewest side effects in this class of medications. They also found that lower doses produced fewer side effects in general.
What is the safest statin drug?
Which statins are the best?
“By using non-HDL-C as a primary measure, we found that the three statins – Rosuvastatin, Simvastatin and Atorvastatin – were ranked most effective in the meta-analysis.”
What is the safest cholesterol medication?
Fortunately, most side effects are mild and disappear promptly when the statin is stopped. In some cases, the problems will resolve simply by reducing the dose or switching to another statin, but care is required. Still, all in all, the statins are the safest and best tolerated of all cholesterol-lowering medications.