How do you make a microemulsion?
Microemulsion systems were prepared by mixing oil with the mixture of surfactant and cosurfactant, and water was added precisely into oily phases with magnetic stirring (300 r/min) at 37°C.
What is microemulsion method?
2 Microemulsion methods. A microemulsion is a thermodynamically stable transparent, isotropic dispersion of two immiscible liquids such as water and oil stabilized by surfactant molecules at the water/oil interface.
What are the characteristics of microemulsion?
Several interesting characteristics of microemulsions, namely, enhanced drug solubilization, good thermodynamic stability, ease of preparation, low viscosity, high drug-loading capacity, and small droplet size, have drawn attention for their use as vehicles for insulin delivery.
What is the size range of microemulsion?
about 10–300 nm
A microemulsion is a thermodynamically stable fluid that differs from kinetically stable emulsions, which will separate into oil and water over time. The particle size of microemulsions ranges from about 10–300 nm. Because of this small particle size, microemulsions appear as clear or translucent solutions.
What is microemulsion polymerization?
Microemulsion polymerization is defined as polymerization involving a radical chain propagation reaction with vinyl monomers in one phase of a microemulsion, and the produced polymer colloid is denoted as latex.
What is the size of microemulsion?
Microemulsions are transperent systems and typically consist of oil, surfactant, cosurfactant and aqueous phase. They are also thermodynamically stable and has a droplet size <0.15 nm and does not have the tendency to coalesce[5,6].
What is global size for microemulsion?
1–100 nm
Conventionally, the term, ‘microemulsion’ refers to a thermodynamically stable, isotropic emulsion with a droplet size of 1–100 nm.
How to prepare microemulsion?
M icroemulsion was prep ared by dissolving rami pril in orange oil. To this glycol was mixed followed by gentle mixing with distilled water. orange oil, tween 80, propylene gl ycol, water is presen ted in Fig.1.
How to check if microemulsion is dilute?
Dilution test To check either microemulsion was a clear, less clear, or milky appearance by visual assessment, the formulated microemulsion system was taken for dilution test. The emulsion should be miscible to the liquid which forms the continuous phase (here oil phase).
How to identify microemulsion emulsion or gel formation?
After each addition of water to the mixture of oil, surfactant, and co-surfactant visual inspection was done to identify the sample as microemulsion, emulsion, or gel formation. Centrifugation
Can water-in-oil microemulsion improve metronidazole solubility?
The microemulsion system proves the efficacy of solubility and dissolution improvement of poorly water- soluble drugs such as metronidazole. The objective of this project work is to prepare and evaluate metronidazole containing topical water-in-oil microemulsion and to compare its effectiveness to other commercially available products.