What are generations of dendrimers?
Structure of PAMAM Dendrimers: Generations 1 through 11
| generation | Rg | RN |
|---|---|---|
| 1 | 7.46 | 10.36 |
| 2 | 9.17 | 11.61 |
| 3 | 11.23 | 12.91 |
| 4 | 14.5 | 16.81 |
Are dendrimers man made?
Dendrimers are man made, nanoscale compounds with unique properties that make them useful to the health and pharmaceutical industry as both enhancements to existing products and as entirely new products. Dendrimers are constructed by the successive addition of layers of branching groups.
How many types of dendrimers are there?
2. Types of dendrimers
| Dendrimer types | Application | Drug |
|---|---|---|
| Polyether dendrimers | Gene delivery | Plasmid DNA |
| Core-shell tecto-dendrimers (G5.0 PAMAM dendrimers as core and G2.5 carboxyl-terminated PAMAM dendrimers as shell | Anticancer activity | |
| Peptide dendrimer | Gene therapy | DNA |
| Dendronized polypeptide (denpol) dendrimer | siRNA delivery | siRNA |
What is the meaning of dendrimers?
Dendrimers are highly ordered, branched polymeric molecules. Synonymous terms for dendrimer include arborols and cascade molecules. Typically, dendrimers are symmetric about the core, and often adopt a spherical three-dimensional morphology. The word dendron is also encountered frequently.
What do dendrimers do?
Dendrimer platforms can be engineered to attach targeting ligands and imaging molecules to create a nanodevice. Dendrimer nanotechnology, due to its multifunctional ability, has the potential to create next generation nanodevices.
Why are dendrimers important?
Due to their size, dendrimers are used in nanomedicine research. They are found to be useful as delivery or carrier systems for drugs and genes, but studies have shown that some dendrimers have medicinal uses of their own, mostly due to their antifungal, antibacterial and cytotoxic properties [5,6].
What are dendrimers in nanotechnology?
Abstract. Dendrimers represent a class of novel polymers having unique molecular architectures characterized by their well-defined structure, with a high degree of molecular uniformity, low polydispersity and properties that make them attractive materials for the development of nanomedicines.
How are dendrimers used in drug delivery?
Dendrimers for drug delivery are employed using two approaches: (i) formulation and (ii) nanoconstruct. In the formulation approach, drugs are physically entrapped in a dendrimer using non-covalent interactions, whereas drugs are covalently coupled on dendrimers in the nanoconstruct approach.
What are dendrimers used for?
How do dendrimers work?
In the different methods, dendrimer grows outward from a multifunctional core molecule. The core molecule reacts with monomer molecules containing one reactive and two dormant groups, giving the first-generation dendrimer. Then, the new periphery of the molecule is activated for reactions with more monomers.