What is Kcentra indicated for?
Kcentra, (Prothrombin Complex Concentrate (Human)), is indicated for the urgent reversal of acquired coagulation factor deficiency induced by Vitamin K antagonist (VKA, e.g., warfarin) therapy in adult patients with acute major bleeding.
What kind of drug is Kcentra?
Kcentra belongs to a class of drugs called Blood Components; Hemostatics.
What medications does Kcentra reverse?
Kcentra is indicated for the urgent reversal of acquired coagulation factor deficiency induced by vitamin K antagonist (VKA, such as warfarin) therapy in adult patients with: Need for urgent surgery or other invasive procedure or. Acute major bleeding.
What is prothrombin complex concentrate used for?
Prothrombin complex concentrates (PCCs) are used mainly for emergency reversal of vitamin K antagonist therapy. Historically, the major drawback with PCCs has been the risk of thrombotic complications.
Does Kcentra reverse Doacs?
The current FDA indications for Kcentra is for reversal of vitamin K dependent procoagulant factors II, VII, IX and X induced by oral vitamin K antagonists such as warfarin or coumadin. There are case reports of Kcentra use in FXa DOAC reversal.
Can Kcentra reverse eliquis?
Cofact may be partially beneficial in the reversal of the anticoagulant effect of apixaban. Kcentra currently is the only nonactivated 4F‐PCC available in the United States, and could potentially have some activity against apixaban induced anticoagulation, but has not been systematically evaluated.
When can I check INR after Kcentra?
INR should be checked 30 minutes after giving Kcentra. If the INR is still > 1.5 give plasma, a 2nd dose of Kcentra should not be given.
How is Kcentra calculated?
Administer Kcentra: By intravenous infusion at a rate of 0.12 mL/kg/min (~3 units/kg/min) up to a maximum rate of 8.4 mL/min. Concurrently with vitamin K.
How fast does Kcentra reverse INR?
Major bleeding despite INR: Administer vitamin K 5-10 mg IV with Kcentra INR will decrease over ~24- 48 hours (oral) and ~12-14 hours (IV); more frequent INR monitoring and additional vitamin K doses may be necessary.
When do we use 4 factor PCC?
Current guidelines recommend 4-factor PCC for situations where rapid reversal of VKA-induced coagulopathy is needed, such as in patients who require urgent surgery or in those with a life-threatening bleed.
What lab value is required for Kcentra?
A single dose of Kcentra is determined by the patient’s pretreatment INR and weight. *Dosing is based on body weight. Dose based on actual potency is stated on the vial, which will vary from 20–31 Factor IX units/mL after reconstitution.