What is the Michael addition product?
The Michael reaction or Michael addition is the nucleophilic addition of a carbanion or another nucleophile to an α,β-unsaturated carbonyl compound containing an electron withdrawing group. It belongs to the larger class of conjugate additions and is widely used for the mild formation of C–C bonds.
What reagent is Michael addition?
Silyl enol ethers are a class of organic compounds which share a common functional group that consists of an enolate bonded to an organosilicon group via an oxygen atom. The catalyst usually used in Mukaiyama-Michael addition reactions is titanium tetrachloride.
Why is Michael addition important?
The Michael addition forms a carbon–carbon bond. A lipase variant catalyzed the Michael addition of acetylacetone to methyl acrylate. The Michael addition forms a carbon–carbon bond, and is thus an important reaction for organic synthesis.
Are Michael additions reversible?
Reversible Michael acceptors have been reported in which an additional electron-withdrawing group was added at the α-carbon of a Michael acceptor. We have performed density functional theory calculations to determine why thiol additions to these Michael acceptors are reversible.
Is aza-Michael addition reversible?
The amide linkages present in these CANs are readily hydrolyzable under mild acidic (pH = 5.3) conditions, whereas the aza-Michael adducts with secondary amines are thermally reversible.
What is Michael addition crosslinking?
Michael type reactions (named after Arthur Michael, 1853-1942) are a broad class of addition reactions in which an unsaturated organic compound (eg vinyl sulfone) reacts with a positively charged (nucleophilic) compound (for example thiols).
Is aza Michael addition reversible?
What is Michael addition polymerization?
Michael addition polymerizations of amines and acrylic monomers are versatile approaches to biomaterials for various applications. A combinatorial library of poly(β-amino ester)s and diverse poly(amido amine)s from diamines and diacrylates or bis(acrylamide)s have been reported, respectively.