What is the indication of tolvaptan?
Tolvaptan is used to treat hyponatremia (low sodium in the blood) in patients with heart failure or syndrome of inappropriate antidiuretic hormone (SIADH). Tolvaptan is also used to slow kidney function decline in adults who are at risk of rapidly progressing autosomal dominant polycystic kidney disease (ADPKD).
What is the mechanism of action of Oprelvekin?
Mechanism of Action: Oprelvekin functions similarly to endogenous interleukin (IL)-11 and stimulates platelet production. The primary hematopoietic activity of oprelvekin is stimulation of megakaryocytopoiesis and thrombopoiesis.
When do you use samsca?
Tolvaptan (Samsca) is used to treat hyponatremia (low levels of sodium in the blood) in people who have heart failure (condition in which the heart cannot pump enough blood to all parts of the body), syndrome of inappropriate antidiuretic hormone (SIADH; condition in which the body produces too much of a certain …
What is Oprelvekin used for?
Naturally occurring interleukin-11 is produced by bone marrow cells in the body and helps to make platelets, which are necessary for proper clotting of blood. Oprelvekin is used to help prevent low platelet counts caused by treatment with some cancer medicines.
What is the best treatment for low sodium?
Treatment
- Intravenous fluids. Your doctor may recommend IV sodium solution to slowly raise the sodium levels in your blood.
- Medications. You may take medications to manage the signs and symptoms of hyponatremia, such as headaches, nausea and seizures.
What medications help hyponatremia?
Medication Summary The primary treatments used in the management of hyponatremic patients rely on the use of intravenous sodium-containing fluids (normal saline or hypertonic saline) and fluid restriction. Less commonly, loop diuretics (eg, furosemide) or demeclocycline are used.
Is Oprelvekin used for thrombocytopenia?
Oprelvekin is indicated for the prevention of severe thrombocytopenia and the reduction of platelet transfusion requirements following myelosuppressive chemotherapy in patients with nonmyeloid malignancies at high risk of severe thrombocytopenia.
What are the side effects of filgrastim?
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- Bleeding gums.
- bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site.
Does tolvaptan increase potassium?
These studies indicate that tolvaptan does not affect potassium metabolism, even though urinary water and sodium excretion is affected by higher doses of tolvaptan.
What medications should be avoided with hyponatremia?
Medications that increase your risk of hyponatremia include thiazide diuretics as well as some antidepressants and pain medications. In addition, the recreational drug Ecstasy has been linked to fatal cases of hyponatremia.
When should filgrastim not be given?
However, do not use it within 24 hours before you begin another chemotherapy. Allow the medicine to warm to room temperature for 30 minutes before you inject it. If the liquid in the prefilled syringe or vial has changed color, looks cloudy, or if you see particles in it, do not use it.
How much water should I drink on tolvaptan?
Because of the way it works, Tolvaptan causes thirst, increased drinking, increased urine volume and frequency and the need to pass urine at night. Typically patients will pass 5-6 litres of urine per day. Therefore you will need to drink 5-6 litres of water or non-caffeinated drinks per day.
Will eating more salt help hyponatremia?
In elderly patients with a diet poor in protein and sodium, hyponatremia may be worsened by their low solute intake. The kidney’s need to excrete solutes aids in water excretion. An increase in dietary protein and salt can help improve water excretion.
How is dilutional hyponatremia treated in congestive heart failure?
Water restriction is a slow and difficult way to treat dilutional hyponatremia during diuretic therapy of congestive heart failure. An i.v. infusion of 400-1 400 mmol hypertonic saline combined with repeated i.v. injections of loop diuretics was used instead in 9 cases (6 patients).
How to administer zinecard to a patient with renal impairment?
Zinecard 1 Recommended Dose. Administer Zinecard Injection via intravenous infusion over 15 minutes. 2 Dose Modifications. Reduce Zinecard dosage in patients with moderate to severe renal impairment… 3 Preparation and Administration. Reconstitute Zinecard with Sterile Water for Injection, USP. 4 Myelosuppression. Zinecard may add to…
How many milligrams of zinecard can you take?
Zinecard (dexrazoxane for injection) is available in 250 mg or 500 mg single dose vials as sterile, pyrogen-free lyophilizates. Do not use Zinecard with non-anthracycline chemotherapy regimens. Zinecard may add to the myelosuppression caused by chemotherapeutic agents.
What is the treatment for hyponatremia with SIADH?
If the cause of the hyponatremia is SIADH, fluid intake needs to be restricted. To control the activity of ADH, certain medications may be used such as demeclocyline, urea or vaptans.