What is the mechanism of action of cefixime?
Cefixime is used to treat a wide variety of bacterial infections. This medication is known as a cephalosporin antibiotic. It works by stopping the growth of bacteria. This antibiotic treats only bacterial infections.
What is the chemical structure of cefixime?
Cefixime trihydrate
| PubChem CID | 5491577 |
|---|---|
| Chemical Safety | Laboratory Chemical Safety Summary (LCSS) Datasheet |
| Molecular Formula | C16H21N5O10S2 |
| Synonyms | Cefixime trihydrate 125110-14-7 Cefixime hydrate Cefixime (trihydrate) UNII-97I1C92E55 More… |
| Molecular Weight | 507.5 |
What drugs interact with cefixime?
Cefixime has moderate interactions with the following drugs:
- bazedoxifene/conjugated estrogens,
- dienogest/estradiol valerate,
- estradiol,
- ethinylestradiol,
- levonorgestrel oral/ethinylestradiol/ferrous bisglycinate,
- probenecid,
- sodium picosulfate/magnesium oxide/anhydrous citric acid,
- voclosporin, and.
Is cefixime broad spectrum?
Cefixime, previously designated FK027, FR17027 and CL284635, is an orally active cephalosporin with a broad spectrum of antibacterial activity in vitro. It is particularly active against many Enterobacteriaceae, Haemophilus influenzae.
Does cefixime cross the blood brain barrier?
Some third generation cephalosporins are effective in therapy for susceptible pathogens in bacterial meningitis, due to their ability to cross the blood-brain barrier. Ceftriaxone, cefotaxime and ceftazidime are used parenterally. Cefpodoxime, ceftibuten, cefdinir and cefixime can be given orally.
Is cefixime a prodrug?
After years of research, is has finally been possible to develop orally active compounds possessing the same antibacterial activity as parenteral third generation cephalosporins, either through the use of prodrugs, or by modifying the molecular structure of drugs. Cefixime is an example of the latter.
What is the mechanism of action of cephalosporins?
Cephalosporins possess a mechanism of action identical to penicillins: inhibition of bacterial cell wall peptidoglycan synthesis by inhibition of penicillin-sensitive enzymes (transpeptidases, carboxypeptidases) that are responsible for the final three-dimensional structure of the rigid bacterial cell wall.
What is the name of the active part of the ceftriaxone molecule?
Ceftriaxone is a third-generation cephalosporin compound having 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetylamino and [(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl side-groups….5.2Related Compounds.
| Same Connectivity | 30 Records |
|---|---|
| Similar Conformers | 23 Records |
Which group is cefixime?
Cefixime is in a class of medications called cephalosporin antibiotics.
What class of antibiotic is cefixime?
Cefixime is used to treat bacterial infections in many different parts of the body. It belongs to the class of medicines known as cephalosporin antibiotics. It works by killing bacteria or preventing their growth.
Is cefixime beta-lactam?
Like all beta-lactam antibiotics, cefixime binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis.
Which antibiotics cross the BBB?
Beta-Lactams Beta lactams penetrate the intact BBB poorly. However in the presence of inflammation penicillins can achieve levels greater than 10x the minimal bactericidal concentration MBC90 for gram positive pathogens (Inf Dis N Am.
Which type of drug penetrate CNS better?
Several anti-infectives (e.g., isoniazid, pyrazinamide, linezolid, metronidazole, fluconazole, and some fluoroquinolones) reach a CSF-to-serum ratio of the areas under the curves close to 1.0 and, therefore, are extremely valuable for the treatment of CNS infections.
Is cefixime bactericidal?
The bactericidal action of Cefixime is due to the inhibition of cell wall synthesis.
What cell structure does cephalosporins target?
Penicillins and cephalosporins are β-lactam antibiotics widely used to treat bacterial infectious diseases. They mainly target the cell wall biosynthesis pathway to inhibit bacterial growth.
How cephalosporin inhibit cell wall synthesis?
Cephalosporins bind to PBPs on bacterial cell membranes to inhibit bacterial cell wall synthesis by mechanisms similar to those of the penicillins. Cephalosporins are bactericidal against susceptible organisms.
What is the mechanism of action of cefotaxime?
Cefotaxime sodium, a parenteral cephalosporin antibiotic, exerts its bactericidal action through inhibition of bacterial cell wall synthesis. Chemical structure modifications have enabled this compound to be resistant to the action of Richmond I, III, IV, and V beta-lactamase enzymes.
What type of antibiotic is cefixime?
Does cefixime cross blood-brain barrier?
Second-generation cephalosporins (e.g. cefuroxime) have additional activity against some Gram-negative bacteria, such as Haemophilus influenzae and Neisseria gonorrhoeae. They are able to penetrate the blood–brain barrier.
How does cefixime work in the body?
Like all beta-lactam antibiotics, cefixime binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis.
How do you determine the structure of Cefixime?
Cefixime (Figure 3, structure 15) is determined on an ODS column with a mobile phase consisting of acetonitrile–water (2.75:7.25) containing 0.01 mol L −1 ammonium acetate and 0.01 mol L −1 tetra- N -butylammonium bromide. Cefixime is detected at 290 nm.
What is the mobile phase of Cefixime?
For analysis of cefixime in serum, an ODS column is used with a mobile phase consisting of 0.3% potassium dihydrogen phosphate–acetonitrile (88.5:11.5). For urine analysis, the mobile phase is a mixture of 0.15% potassium dihydrogen phosphate–acetonitrile (77:23) containing 0.1% phosphoric acid.
Does cefixime interfere with autolysin inhibitors?
Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefixime interferes with an autolysin inhibitor. Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients