Can fibrous dysplasia be mistaken for cancer?
The locally aggressive variant of fibrous dysplasia may be confused with a malignant tumor or malignant degeneration of fibrous dysplasia. It is important to properly evaluate these lesions to ensure that a proper diagnosis is made, especially with respect to a malignant versus benign mass.
How do you diagnose fibrous dysplasia?
The primary tool for diagnosis of fibrous dysplasia is an X-ray. While bone appears solid in an X-ray, a fibrous dysplasia lesion has a relative distinct appearance often described as “ground glass.” The condition may be diagnosed, therefore, even in a person with no symptoms who is getting an X-ray for other reasons.
Why is ground glass appearance seen in fibrous dysplasia?
Ground glass opacification results from the superimposition of a myriad of poorly calcified bone trabeculae arranged in a disorganized pattern. Orange peel appearance with stippling is seen in some cases. Lamina dura of teeth in the affected area may be lost. This is quite common in the maxilla.
What are the main features of fibrous dysplasia?
Bone pain, usually a mild to moderate dull ache. Swelling. Bone deformity. Bone fractures, particularly in the arms or legs.
What mimics fibrous dysplasia?
Abstract. Fibrous dysplasia can be monostotic or, less commonly, polyostotic. The imaging features of polyostotic fibrous dysplasia may closely mimic those of metastatic bone disease, Paget disease, or enchondromatosis (Ollier disease).
Which of these characteristic histological features are found in fibrous dysplasia?
Histologically, fibrous dysplasia is composed of fibrous tissue with irregular, randomly oriented bony trabeculae. The fibrous stroma is composed of low cellularity, with bland fibroblasts with a spindle cell appearance in a dense collagenous matrix showing a whorled or storiform pattern.
What is McCune-Albright syndrome?
McCune-Albright condition is an extremely rare disease that affects the bones, the skin and the endocrine system. Children with McCune-Albright condition have weakened bones that break easily. The disorder is present at birth, but symptoms may not appear until later in childhood.
What is the significance of ground glass opacity?
Pure ground-glass opacity (GGO) nodules are important indicators of lung cancer on CT. GGO nodules are defined as hazy areas, which do not block the parenchymal structures, vessels, and airways under the nodules 3, 4.
What does fibrous dysplasia look like on xray?
Plain radiograph The appearance of fibrous dysplasia is usually smooth and homogeneous with endosteal scalloping and cortical thinning 5. The borders are well defined and the cortex is usually intact but thinned due to the expansive nature of the lesion 5. Other features include: ground-glass matrix.
What doctor treats fibrous dysplasia?
Patients with fibrous dysplasia who consult with their doctors are referred to an experienced orthopedic specialist like Dr. Allison who is best qualified to diagnose and treat the condition. Dr. Allison will order more tests to confirm the diagnosis and ascertain the extent of the disorder.
Do all tumors show up on CT scans?
5 Cancers a CT Scan Can Easily Detect But not every cancer has a regular screening test—especially if you have a cancer that’s harder to detect. That’s where a CT scan for cancer comes in.
What is polyostotic fibrous dysplasia?
Polyostotic fibrous dysplasia — More than one bone is involved. It can affect more than one bone within the same limb or multiple bones throughout the body. This form of the condition is usually more severe. For this reason, it is typically discovered earlier in life.
What percent of ground-glass nodules are cancerous?
Ninety-three percent of nodules larger than 20 mm, 75% of nodules 10 to 20 mm, and 43% of nodules < or =10 mm were malignant.
What is the prognosis of fibrous dysplasia?
Individuals with milder forms of FD often live normal, otherwise healthy lives. The prognosis is as widely variable as the disorder itself, and is based on the bones affected, whether other structures such as nerves are affected, and whether fractures occur.
Is fibrous dysplasia and autoimmune disease?
Fibrous dysplasia of bone (FD) is a benign skeletal disorder with a broad spectrum of severity.