How do you calculate f1 factor difference?
Difference Factor The difference factor (f1 ) calculates the percent (%) difference between the two curves at each time point and is a measurement of the relative error between the two curves: f1= {[Σ t=1 n |R-T|] / [Σ t=1 n R]} ×100 where n is the number of time points, R is the dissolution value of the reference ( …
How do you calculate f1 and f2 in dissolution?
The factor f1 is proportional to the average difference between the two profiles, where as factor f2 is inversely proportional to the average squared difference between the two profiles, with emphasis on the larger difference among all the time-points. The factor f2 measures the closeness between the two profiles.
How do you calculate dissolution factor?
Formula for determination of percentage of release of drug from in vitro dissolution testing
- Concentration of drug (µg/ml)= (slope × absorbance) ± intercept.
- Amount of drug = Concentration × Dissolution bath volume × dilution factor.
What is f1 value in dissolution?
Fit factors The factor, f1, is the average % difference over all time points in the amount of test brand dissolved as compared to the reference brand. The f1 value is 0 when the test and the reference profiles are identical and increases proportionally with the dissimilarity between the two profiles.
What is dissolution factor?
Solubility of drug plays a prime role in controlling its dissolution from dosage form. Aqueous solubility of drug is a major factor that determines its dissolution rate. Minimum aqueous solubility of 1% is required to avoid potential solubility limited absorption problems.
How do you calculate similarity factor?
2, wt=1+{(%CVof Rt)/ (MCVE/L)}+{(%CV of Tt)/(MCVE/L)}–(2), where, wt is weight, %CV of Rt and %CV of Tt are the percentage coefficient of variation of reference and test products respectively. MCVE/L is the maximum allowable %CV.
What are F1 and f2?
While in F1, every team has their own car models and manufacturers, including tech that they have developed themselves to have a better shot at winning the event, in F2, all drivers have to use a car designed by Williams F1. All cars are ditto, and all drivers are catered to by the same race engineers.
What is f1 and f2 factor in dissolution PDF?
Factor f1 indicates the percentage difference (dissimilarity) between two dissolution profiles; f2 is the logarithm of the reciprocal square root transformation of the sum squared error. It indicates the average percentage of similarity between two dissolution profiles.
What is S1 S2 S3 in dissolution?
In stage S3, another 12 units are to be analyzed, the average of 24 units (S1+S2+S3) should be equal to or more than Q and no unit is less than Q-25% and not more than 2 units are less than Q-15%. In this S3 dissolution stage, 3 units are acceptable below Q, which gives more flexibility.
What is F1 F2 F3?
F1, F2, and F3 are all Formula racing leagues. F1 is the fastest, most expensive, and most prestigious. F2 and F3 run less powerful cars, but more drivers and are very exciting races. F1 is the ultimate Formula racing league. Some F2 and F3 drivers are promoted to Formula 1 if they have the skill.
What is similarity factor f2?
Conclusions: The similarity factor f2 is a simple measure for the comparison of two dissolution profiles. But the commonly used similarity factor estimate f2 is a biased and conservative estimate of f2. The bootstrap approach is a useful tool to simulate the confidence interval.