How high is IgG in multiple myeloma?
In people with multiple myeloma, 70% have high levels of IgG protein, 20% have high levels of IgA and 5–10% produce only immunoglobulin light chains (Bence-Jones proteins).
What are good numbers for multiple myeloma?
Normal range: 0.57-2.63 mg/dL Multiple myeloma or another plasma cell disorder may be indicated by increased lambda free light chains and a decreased kappa/ lambda ratio.
What is a high monoclonal protein?
Overview. Monoclonal gammopathy of undetermined significance (MGUS) is a condition in which an abnormal protein — known as monoclonal protein or M protein — is in your blood. This abnormal protein is formed within your bone marrow, the soft, blood-producing tissue that fills in the center of most of your bones.
What is the normal range for kappa?
Normal results from a kappa free light chain test depend on the testing method and the lab’s established reference ranges. The normal ranges for free light chains are generally: 3.3 to 19.4 milligrams per liter (mg/L) kappa free light chains. 5.71 to 26.3 mg/L lambda free light chains.
What is considered a high level of M-protein?
People who have high-risk MGUS have any of the following features: The M-protein level is more than 15 g/L. The type of M-protein is IgA or IgM.
What is a high kappa light chain value?
In general, a low kappa-lambda ratio (< 0.26) indicates the overproduction of lambda light chains, and a high ratio (> 1.65) indicates the overproduction of kappa light chains.
What is normal monoclonal protein level?
Monoclonal gammopathy of undetermined significance (MGUS) is defined as a serum M protein level of less than 3 g/dL, less than 10% clonal plasma cells in the bone marrow, and the absence of end-organ damage.
What is a normal M spike range?
Normal range: 1.21-2.70 mcg/mL. B2M is a protein produced by malignant cells. It can be a useful indicator of a patient’s prognosis (outlook). High levels mean the disease is more advanced and may indicate a poor prognosis. M spike (myeloma gamma globulin)9,16,30.
What levels are elevated in multiple myeloma?
People with smoldering myeloma have some signs of multiple myeloma, such as any of the following: Plasma cells in the bone marrow between 10% and 60% High level of monoclonal immunoglobulin (M protein) in the blood. High level of light chains in the urine (also called Bence Jones protein)
What is monoclonal IgG Kappa?
The most common type of myeloma is IgG kappa. In IgG kappa myeloma, the myeloma cells produce an immunoglobulin made from two IgG heavy chains bound to two kappa light chains. About 15% of patients have light chain myeloma. In this type of myeloma, the myeloma cells secrete only light chain protein and no heavy chains.
What is IgG multiple myeloma?
What is considered a high M spike?
Patients with a higher M spike (greater than 1.5 g/dL) or abnormal SFLC ratio are at a higher risk of disease progression. In addition, patients with IgM or IgA MGUS have a higher rate of developing myeloma than patients with IgG MGUS.
What is considered high risk MGUS?
People who have high-risk MGUS have any of the following features: The M-protein level is more than 15 g/L. The type of M-protein is IgA or IgM. The free light chain ratio is abnormal.
What is the normal range of IgG?
Normal Ranges Adult: IgG 6.0 – 16.0g/L. IgA 0.8 – 3.0g/L.
What is MGUS IgG?
– Serum monoclonal protein level greater than or equal to 15 g/L (1.5 g/dL) – Non-IgG MGUS (i.e., IgA, IgM, and IgD MGUS) – Abnormal serum free light chain ratio
What is light chain disease kappa type?
One type of myeloma is Kappa light chain myeloma. With this disorder, there’s an overabundance of a specific antibody protein – the Kappa light chain protein. There’s no cure for multiple myeloma, but it can be controlled. Mercy cancer specialists can provide treatment and management strategies such as:
What is the normal Kappa to lambda ratio?
The exact normal ratio of kappa to lambda, according to a novel polyclonal free light chain assay, ranges from 0.26 to 1.65. Both the kappa and the lambda chains can increase proportionately, maintaining a normal ratio. This is usually indicative of something other than a blood cell dyscrasia, such as kidney disease.
What is IgG Kappa paraprotein?
IgG Kappa and IgA Lambda. These are then measured as two different paraproteins and is referred to as bi-clonal myeloma. Each immunoglobulin has their own role to play in the immune system as outlined in the table below. Immunoglobulin Type Usual Function IgG Most common immunoglobulin.