Is monoclonal gammopathy of undetermined significance cancer?
MGUS (monoclonal gammopathy of unknown significance) is a non-cancerous condition where the body makes an abnormal protein, called a paraprotein. MGUS is not a cancer, but people with it have a slightly higher risk of developing: myeloma (a cancer of blood cells called plasma cells)
Is MGUS asymptomatic?
Monoclonal gammopathy of undetermined significance (MGUS) is a clinically asymptomatic premalignant clonal plasma cell or lymphoplasmacytic proliferative disorder.
Is it good to have no monoclonal protein detected?
If a monoclonal protein is identified, its immunoglobulin class (IgG, IgA, IgM, IgD, IgE) and light chain type (kappa, lambda) are determined by immunofixation. If no monoclonal protein is detected, further testing is not warranted….Immunofixation.
| Gammopathy | % @ SLH | % @ Mayo |
|---|---|---|
| IgA | 11 | 11 |
| Light chain | 5 | 5 |
| Biclonal | 5 | 4 |
How is monoclonal gammopathy of undetermined significance diagnosed?
Diagnosing MGUS MGUS is usually detected incidentally during a routine check-up when a blood test shows an increase in the blood protein level. The diagnosis is then confirmed by having a particular blood test called serum electropheresis which identifies the abnormal antibody.
Does MGUS cause fatigue?
Your doctor is likely to watch for signs and symptoms such as: Bone pain. Fatigue or weakness. Unintentional weight loss.
Is MGUS a serious condition?
MGUS usually causes no problems. But sometimes it can progress to more-serious diseases, including some forms of blood cancer. If you have high amounts of this protein in your blood, it’s important to have regular checkups so that you can get earlier treatment if it does progress.
Does MGUS cause hip pain?
Multiple myeloma can cause pain in affected bones – usually the back, ribs or hips. The pain is frequently a persistent dull ache, which may be made worse by movement.
Does MGUS cause weight gain?
They analyzed data from 7,878 patients, most of whom were men, who were diagnosed with MGUS from October 1999 through December 2009. The patients consisted of 39.8 percent who carried extra weight and 33.8 percent who were obese.
What was your first symptom of multiple myeloma?
Symptoms and conditions caused by multiple myeloma The early signs, which can vary among individuals, include: Bone pain (particularly in the spine and ribs) Excessive bruising or bleeding. Unexplained bone fractures (especially in the spinal vertebrae)