Is Pluronic and poloxamer the same?
Poloxamers, also known as Pluronics®, are block copolymers of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO), which have an amphiphilic character and useful association and adsorption properties emanating from this.
What is poloxamer 188 used for?
Poloxamer 188 is a medication used to clean wounds. Poloxamer 188 (P188) is a nonionic block linear copolymer that exhibits rheologic, anti-thrombotic, anti-inflammatory, and cytoprotective activities in various tissue injury models 5.
Is poloxamer 188 a surfactant?
Poloxamer P188 is a nonionic copolymer surfactant with a triblock structure, comprised of two hydrophilic segments, the poly(oxyethylene) (PEO), and a central hydrophobic segment, the poly(oxypropylene) (PPO), taken together by ether bonds.
What is poloxamer made of?
Pluronics® or poloxamers are tri-block copolymers of poly(ethylene oxide) poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) (Lippens et al., 2013). This group of synthetic polymers is thermoreversible in aqueous solutions.
Is poloxamer 188 the same as Pluronic F68?
Poloxamer 188 (Pluronic F-68, Flocor™) in its entirety is a complex polydisperse mixture of non-ionic macromolecules [1]. Each molecule consists of a central polypropylene oxide chain flanked at either end by a polyethylene oxide segment, thus forming an ABA block copolymer structure.
Is poloxamer 188 toxic?
Poloxamer 188 (P188) is a nonionic block copolymer chemical surfactant known to have cytoprotective, rheologic, anti-inflammatory, and anti-thrombotic activity combined with minimal toxicity.
Is Pluronic F68 the same as poloxamer 188?
Is poloxamer soluble in water?
All poloxamers are freely soluble in water and in alcohol. Poloxamer 124 is freely soluble in isopro- pyl alcohol and in propylene glycol; poloxamer 237 is sparingly soluble in isopropyl alcohol and in xylene; poloxamer 338 is sparingly soluble in propylene glycol; poloxamer 124 is freely soluble in xylene.
Is Pluronic FDA approved?
Pluronics (PEOx-PPOy-PEOx) are non-ionic triblock copolymers composed of two hydrophilic side chains of poly (ethylene oxide), PEO, and a central hydrophobic chain of poly (propylene oxide), PPO. They are also known as poloxamers and are non-toxic, biodegradable and FDA approved [22].
What is the function of Pluronic F68?
Pluronic F68 is used in cell culture as a stabilizer of cell membranes protecting from membrane shearing and additionally acts as an anti-foaming agent.
Is Pluronic biodegradable?
Moreover, Pluronic F-127 hydrogel has favorable properties such as non-toxicity, biocompatibility, and biodegradability.
Is poloxamer 188 the same as Pluronic f68?
Is poloxamer a surfactant?
Poloxamers are a major non‐ionic surfactant, which are widely applied in wound care. They are triblock copolymers composed of a central hydrophobic chain of polyoxypropylene (poly[propylene oxide], PPO) flanked by two hydrophilic chains of polyoxyethylene (poly[ethylene oxide], PEO).
What is poloxamer 188 (p188)?
Poloxamer 188 (P188) is a nonionic linear copolymer having an average molecular weight of 8400 Daltons and is also referred to as PLURONIC F68, FLOCOR and RheothRx. The copolymer was approved by the FDA nearly 50 years ago as a therapeutic reagent to reduce viscosity in the blood before transfusions.
Does poloxamer 188 form micelles?
In aqueous solution, poloxamer 188 forms micelles and these structures are believed to initiate complement activation. Therefore, we assessed the cmc of poloxamer 188 as well as micellar size distribution. The micelle formation in poloxamer 188 solutions was temperature sensitive.
Is poloxamer 188 a useful surfactant in biological formulations?
Concluding, the state of scientific knowledge regarding poloxamer 188 as surfactant in biological formulations is not on the same level with that for polysorbates. Researchers have proofed for certain examples the ability to protect proteinic drugs from denaturation and aggregation so far.
Does poloxamer 188-mediated complement activation depend on polydispersity?
Poloxamer 188-mediated complement activation is an intrinsic property of these macromolecules and was independent of the degree of sample polydispersity, as opposed to other non-polymeric constituents. Poloxamer 188 preparations also contained unsaturated chains of diblock copolymers capable of generating SC5b-9 in human sera;