What are the symptoms of spastic paraplegia?
The primary symptom of HSP is difficulty walking due to weakness and tightness (spasticity) in the legs. Both legs are affected, usually to a relatively similar degree. The term “paraplegia” means severe weakness in both legs including paralysis.
What is the treatment for spastic paraplegia?
Treatment is exclusively symptomatic and aimed mainly at reducing muscle spasticity and urinary urgency, and improving strength and gait. Therapeutic options include physical therapy, oral antispastic drugs (baclofen, progabide, dalfampridine), botulinum toxin therapy, and surgical baclofen pump implantation.
What disease causes spastic paralysis?
Causes. Infantile-onset ascending hereditary spastic paralysis is caused by mutations in the ALS2 gene. This gene provides instructions for making the alsin protein. Alsin is produced in a wide range of tissues, with highest amounts in the brain, particularly in motor neurons.
Can someone with spastic paraplegia walk?
Children may develop leg stiffness and problems walking, such as stumbling and tripping, particularly on uneven ground. This is because it’s difficult for them to bend their toes upwards as a result of having weak hip muscles.
Is spastic paraplegia cerebral palsy?
Spastic diplegia presenting in infancy is common to both cerebral palsy (CP) and hereditary spastic paraplegia (HSP). We report the clinical and genetic features of a cohort of Alberta patients with a diagnosis of HSP, who were initially diagnosed with CP.
What are the symptoms of spasticity?
Symptoms
- Muscle stiffness, causing movements to be less precise and making certain tasks difficult to perform.
- Muscle spasms, causing uncontrollable and often painful muscle contractions.
- Involuntary crossing of the legs.
- Muscle and joint deformities.
- Muscle fatigue.
- Inhibition of longitudinal muscle growth.
What is a TSP test?
The traveling salesman problem (TSP) is a combinatorial optimization problem that requires finding the shortest path through a set of points (“cities”) that returns to the starting point.
Does spastic paraplegia affect the brain?
Description. Spastic paraplegia type 7 (also called SPG7) is one of more than 80 genetic disorders known as hereditary spastic paraplegias. These disorders primarily affect the brain and spinal cord (central nervous system), specifically nerve cells (neurons) that extend down the spinal cord.
How is spasticity diagnosed?
Testing & Diagnosis A physical examination with neurological testing will be done to test for spasticity and the severity of it. Imaging such as magnetic resonance imaging (MRI) can provide more information on the source of spasticity and the extent of the damage that has caused it.
What is Tsplib?
TSPLIB is a text-based file format for storing graphs which is used in studying instances of the Traveling Salesman Problem and related problems. • The format consists of a sequence of node definitions, followed by a list of edges, which specify node pairs and an optional edge label.
What is a G ratio serum in blood test?
A total protein and albumin/globulin (A/G) ratio test measures the total amount of protein in your blood. There are two major types of protein in the blood: Albumin, which helps keep blood from leaking out of blood vessels.
What is the miracle drug that dissolves blood clots?
Patients who don’t get to the hospital within 90 minutes of stroke symptoms starting may not be eligible to receive an effective “clot-busting” drug called tPA. tPA quickly dissolves the clots that cause many strokes.
What is spastic paraplegia 11?
Summary Summary. Spastic paraplegia 11 (SPG11) is a form of hereditary spastic paraplegia. People with SPG11 experience worsening muscle stiffness leading to eventual paralysis of the lower limbs, as well as a range of other neurologic symptoms that may include intellectual disability, speech difficulties (dysarthria), and reduced bladder control.
What is the pathophysiology of hereditary spastic paraplegia?
In hereditary spastic paraplegia, upper motor neurons slowly degenerate so the muscles do not receive the correct messages, causing progressive spasticity (increased muscle tone/stiffness) and weakness of the legs.
How many types of spastic paraplegia are there?
Overview The hereditary spastic paraplegias (HSP) are a large group of inherited neurologic disorders that share the primary symptom of difficulty walking due to muscle weakness and muscle tightness (spasticity) in the legs. There are more than 80 different genetic types of HSP.
What are the signs and symptoms of paraplegia and paraparesis?
Signs & Symptoms. “Paraparesis” indicates weakness in both legs of lesser severity than paraplegia. Although the disorder is typically referred to as hereditary spastic paraplegia the degree of weakness is variable and ranges from no weakness (full strength) to marked weakness (paraplegia).