What does high MMP-9 mean?
Notably, high levels of MMP-9 have been associated with plaque progression, destability and rupture. These various effects exaggerate the inflammatory process, promoting atherosclerosis and increasing the risk of atherothrombosis and cardiovascular (CV) events.
What are normal levels of MMP-9?
In contrast, the MMP-9 serum levels in 47 healthy individuals ranged from 30 to 537 ng/ml (mean, 189 ng/ml), MMP-9 serum concentration being significantly higher in HNSCC patients (p = 0.001).
What causes high MMP-9?
MMP-9 has been associated with chronic inflammatory autoimmune diseases, including rheumatoid arthritis, Sjögren’s syndrome, idiopathic uveitis, and systemic lupus erythematosus [16–19].
What is MMP in skin?
UV radiation increases the expression of matrix metalloproteinases (MMPs) in human skin. MMPs are responsible for degrading the extracellular matrix (ECM) proteins such as collagen, fibronectin, elastin, and proteoglycans, contributing to photoaging [3,4].
How can I lower my MMP-9?
EPA and DHA significantly decreased MMP-9 protein levels, MMP-9 activity, and significantly inhibited human T cell migration. The data suggest that omega-3 fatty acids may benefit patients with multiple sclerosis by modulating immune cell production of MMP-9.
What does high MMP mean?
Matrix metalloproteinases (MMPs) are crucially involved in the regulation of multiple stages of cancer progression. Elevated MMP levels have been associated with the development of metastases and poor prognosis in several types of cancer.
How do I lower my MMP-9?
Where are MMP found?
The cluster in the human genome is located at chromosome 11q22 and contains MMP-1, -3, -7, -8, -10, -12, -13, -20 and -27. In contrast, most of the other human MMP genes are located on different chromosomes, resulting in a total of 10 distinct chromosomes for all 24 human MMP genes [1].
Which cell types would produce MMP-9?
MMP-9 is secreted by a wide number of cell types, including neutrophils, macrophages, and fibroblasts. Neutrophils contain multiple proteases, such as serine proteases (elastase, cathepsin G, and proteinase 3), MMPs (MMP-8 and -9), and urokinase plasminogen activator (uPA).
What does MMP-9 test for?
Additional Information. MMP-9 is a marker of inflammation, tissue remodeling, wound healing, and mobilization of tissue-bound growth factors and cytokines.
What causes high matrix metalloproteinases?
2.3. However, most MMPs are induced in response to tissue injury or infection and function in a wide range of wound repair, inflammation and defense processes against the external environment [19].
What does MMP mean?
Medicare-Medicaid Plan (MMP) Enrollment.
What is the function of MMP?
MMPs Functions The principal biologic function of MMPs is degradation of ECM proteins and glycoproteins [1,2,6,8,11,12,14,16,18,19,24,31], membrane receptors [13,14,24,31], cytokines [11,13,14,31], and growth factors [11,13,14,24,31].
How do I lower my MMP?
MMP-9 has been shown to be decreased by other immunomodulators such as IFN-β22, 23 and minocycline. Both drugs are also highly effective in reducing enhancing lesions on MRI by approximately 80% within the first 3 months of treatment.
What is the function of MMPs?
Function. The MMPs play an important role in tissue remodeling associated with various physiological or pathological processes such as morphogenesis, angiogenesis, tissue repair, cirrhosis, arthritis, and metastasis.
What is MMP blood test?
Code: MMP9. Test Overview : Matrix metalloproteinase-9(MMP-9) is a marker of inflammation, tissue remodeling and wound healing. This enzyme contributes to the pathogenesis of rheumatoid arthritis, coronary artery disease, chronic obstructive pulmonary disease, multiple sclerosis, asthma, and cancer.