What does LEP Gene stand for?
LEP (Leptin) is a Protein Coding gene. Diseases associated with LEP include Leptin Deficiency Or Dysfunction and Eating Disorder. Among its related pathways are Peptide hormone metabolism and Adipogenesis.
What gene encodes leptin?
The LEP gene provides instructions for making a hormone called leptin, which is involved in the regulation of body weight. Normally, the body’s fat cells release leptin in proportion to their size. As fat accumulates in cells, more leptin is produced.
Where does leptin bind?
Leptin binds to its receptors in the hypothalamus, where it acts through the sympathetic nervous system to regulate bone metabolism.
What is the ob gene?
The ob gene product, called leptin, is a recently discovered hormone secreted by the adipose cells. By acting as a satiety factor and increasing energy expenditure, leptin plays a major role in body weight homeostasis in mice.
Does eating fat increase leptin?
When you eat, your body fat goes up, leading your leptin levels to go up. Thus, you eat less and burn more. Conversely, when you don’t eat, your body fat goes down, leading your leptin levels to drop. At that point, you eat more and burn less.
What is leptin deficiency symptoms?
Leptin receptor deficiency is a condition that causes severe obesity beginning in the first few months of life. Affected individuals are of normal weight at birth, but they are constantly hungry and quickly gain weight. The extreme hunger leads to chronic excessive eating (hyperphagia) and obesity.
What inhibits leptin?
By inhibiting leptin secretion from white adipose tissue, norepinephrine may decrease plasma leptin levels and consequently reduce the activity of the sympathetic nervous system.
What is ob and db mice?
Ob/ob mice are characterized by a mutation of the obese (ob) gene encoding leptin, whereas the db/db mice have a mutation of the diabetes (db) gene encoding for the ObR [20].
What does ob gene code for in mice?
The recently identified mouse obese (ob) gene apparently encodes a secreted protein that may function in the signaling pathway of adipose tissue. Mutations in the mouse ob gene are associated with the early development of gross obesity.
How do I test my leptin levels?
What test measures leptin levels? A blood test can check the amount of leptin in a blood sample taken from a vein in your arm.
Are ob ob mice diabetic?
The C57BL/6 and BTBR strains, when made obese by introduction of the ob/ob mutation, differ significantly in their diabetes susceptibility; C57BL/6 ob/ob mice are insulin resistant but relatively diabetes resistant, whereas BTBR ob/ob mice are insulin resistant and develop severe diabetes.
What does db db mice mean?
Definition. The db/db mouse is a genetically mutated mouse in which leptin receptors do not function properly. The db / db mouse is extremely obese and has many of the metabolic defects (hyperphagia, hyperglycemia, hyperinsulinemia, and infertility) found in ob/ob mouse.
What is DB DB and ob ob mice?
What do you eat on the Leptin Diet?
The leptin diet allows you to eat a wide range of vegetables, fruits, and protein sources, including fish, meat, chicken, and turkey. Fruit, rather than sugar-dense desserts, is the suggested dessert option. You can also eat nut butters in moderation, eggs, and cottage cheese.