What is Macrothrombocytopenia?
Giant platelet disorders, also known as macrothrombocytopenia, are rare disorders featuring abnormally large platelets, thrombocytopenia and a tendency to bleeding. Giant platelets cannot stick adequately to an injured blood vessel walls, resulting in abnormal bleeding when injured.
What is the most common cause of increased platelet destruction?
The most common cause of thrombocytopenia is increased destruction of platelets. Platelets are eliminated from peripheral circulation faster than the bone marrow can produce new platelets. Increased platelet destruction may be the result of immune or nonimmune mechanisms.
What causes platelets to be destroyed?
Autoimmune diseases, such as immune thrombocytopenia (ITP), lupus, and rheumatoid arthritis can cause your immune system to attack and destroy your platelets by mistake. Cancer, such as leukemia or lymphoma, can damage your bone marrow and destroy blood stem cells.
What causes giant and large platelets?
Giant platelets are occasionally observed as an incidental finding in routine blood smear examina- tions. Most of them are due to acquired disorders such as idiopathic thrombocytopenic purpura (ITP) and myelodysplastic syndrome (MDS) (Table I). In contrast, inherited giant platelet disorders are rare.
What are two disorders of macrothrombocytopenia?
The syndromes MHA, Epstein syndrome (EPS), Fechtner Syndrome (FS), and Sebastian platelet syndrome (SPS) are recognized to be related disorders, associated with the mutations in the MYH9 gene [20].
What is the other name of the platelets?
Platelets, or thrombocytes, are small, colorless cell fragments in our blood that form clots and stop or prevent bleeding.
What is the difference between large platelets and giant platelets?
Large platelets have a diameter greater than 4 microns. Giant platelets have a diameter greater than 7 microns (larger than a normal red blood cell). Large platelets can be seen when platelet turnover is increased (as in immune thrombocytopenic purpura).
Is macrothrombocytopenia hereditary?
The phenomenon of reduced platelet count than normal (i.e. < 150,000/µL) with a significant increase in platelet size (> 12 fl) [2] is termed as Macrothrombocytopenia [1, 2]. This clinical phenomenon can be either acquired or inherited.
What are the main mechanisms of thrombocytopenia?
There are four primary causes of thrombocytopenia: hypoproliferation (lack of production), sequestration, consumption (utilization), and destruction. Sampling or laboratory artifact may also lead to falsely low platelet counts.
What’s another name for platelet?
Platelets, also known as thrombocytes, are blood cells. They form in your bone marrow, a sponge-like tissue in your bones. Platelets play a major role in blood clotting.