What is melanoma Wikipedia?
Melanoma, also redundantly known as malignant melanoma, is a type of skin cancer that develops from the pigment-producing cells known as melanocytes. Melanomas typically occur in the skin, but may rarely occur in the mouth, intestines, or eye (uveal melanoma).
What are the stages of melanoma?
Overview of Stages O-IV
- Stage 0 Melanoma (in situ)
- Stage I Melanoma (localized tumor)
- Stage II Melanoma (localized tumor)
- Stage III Melanoma (regional spread)
- Stage IV Melanoma (metastasis beyond regional lymph nodes)
- Brain Metastases.
Is melanoma Stage 1 curable?
Prognosis for Stage 1 Melanoma: With appropriate treatment, Stage I melanoma is highly curable. There is low risk for recurrence or metastasis. The 5-year survival rate as of 2018 for local melanoma, including Stage I, is 98.4%.
Is stage 1a melanoma serious?
Stage 1 is considered a ‘thin melanoma’. If your melanoma is caught before it is too thick the prognosis is very good. Nearly 19 in 20 people who have a stage 1 melanoma are alive at least five years after being diagnosed. Stage 1 is the least serious type of melanoma.
What happens if you have stage 1 melanoma?
Stage I Melanoma This is a noninvasive stage, which is also called melanoma “in situ,” meaning “in its original place.” With stage I melanoma, the tumor’s thickness is 1mm or less. This tumor may or may not have ulcerated, and it isn’t yet believed to have spread beyond the original site.
How long can you have stage 1 melanoma?
Prognosis for Stage 1 Melanoma: With appropriate treatment, Stage I melanoma is highly curable. There is low risk for recurrence or metastasis. The 5-year survival rate as of 2018 for local melanoma, including Stage I, is 98.4%. Click here to learn more about melanoma survival rates.
What is the effect of inhibition of melanoma inhibitory activity?
Tatzel J, Poser I, Schroeder J, Bosserhoff AK (2005). “Inhibition of melanoma inhibitory activity (MIA) expression in melanoma cells leads to molecular and phenotypic changes”. Pigment Cell Res. 18 (2): 92–101. doi: 10.1111/j.1600-0749.2005.00212.x. PMID 15760338.
What is melanoma-inhibiting activity (Mia)?
“Melanoma-inhibiting activity, a novel serum marker for progression of malignant melanoma”. Cancer Res. 57 (15): 3149–53. PMID 9242442. Bosserhoff AK, Hein R, Bogdahn U, Buettner R (1996). “Structure and promoter analysis of the gene encoding the human melanoma-inhibiting protein MIA”. J. Biol. Chem. 271 (1): 490–5. doi: 10.1074/jbc.271.1.490.
What is the role of HMG1 in the pathophysiology of melanoma?
Poser I, Golob M, Buettner R, Bosserhoff AK (2003). “Upregulation of HMG1 leads to melanoma inhibitory activity expression in malignant melanoma cells and contributes to their malignancy phenotype”. Mol. Cell. Biol. 23 (8): 2991–8. doi: 10.1128/MCB.23.8.2991-2998.2003. PMC 152547. PMID 12665595.
Is Mia a key molecule regulating melanoma progression?
The protein MIA, which is strongly expressed in melanoma cells but not in melanocytes, is likely to represent a key molecule regulating melanoma progression.