What is the difference between KCentra and Feiba?
FEIBA® is current formulary activated prothrombin complex concentrate (aPCC) product. KCentra® is current formulary prothrombin complex concentrate (PCC) product. Kcentra™ contains clotting factors II, VII, IX and X. It contains heparin and use should be avoided in patients where heparin is contraindicated.
What is the reversal agent for dabigatran?
Idarucizumab, an antibody fragment, was developed to reverse the anticoagulant effects of dabigatran.
What is the reversal agent for heparin?
Background Protamine is used to reverse the anticoagulant effects of heparin, but it can have important side effects. Platelet factor 4 (PF4) is a protein found in platelet alpha granules that binds to and thereby neutralizes heparin.
Which is the anticoagulant of choice for obese patients?
In patients with a BMI of 40-50 kg/m2, warfarin should be used, but apixaban or edoxaban can be considered. In obese patients with a BMI > 50 kg/m2, warfarin should be used.
Does PCC reverse dabigatran?
In an animal bleeding model, PCC reversed the effect of dabigatran on hemostatic parameters but had no effect on coagulation assays.
Is Praxbind a biologic?
About the PRAXBIND Clinical Trial Program The company completed three phase I trials of PRAXBIND in healthy volunteers, and included these data in the PRAXBIND biologics license application (BLA) it submitted to the U.S. Food and Drug Administration.
Which DOAC should never be opened or crushed?
Apixaban, dabigatran, edoxaban can be taken with or without meals. However, taking dabigatran with meals can reduce dyspepsia. Dabigatran capsules should not be opened, broken or chewed before swallowing.
Are DOACs lipophilic?
DOACs have been reported as moderately lipophilic13 with edoxaban as the least lipophilic (log P 0·90 to 1·61), followed by rivaroxaban (log P 1·74 to 1·90), apixaban (log P 1·83 to 2·22) and finally dabigatran with the highest lipophilicity (log P 4·59 to 5·17).
What is FEIBA and how does it work?
FEIBA is an Anti-Inhibitor Coagulant Complex approved for use in hemophilia A and B patients with inhibitors for: Control and prevention of bleeding episodes. Use around the time of surgery. Routine prophylaxis to prevent or reduce the frequency of bleeding episodes.
What factors does FEIBA have?
FEIBA contains several different clotting factors—factors II, IX, and X, mainly non-activated; and factor VII, mainly in the activated form. FEIBA acts at multiple sites in the clotting cascade.
Why is Kcentra contraindicated in DIC?
Kcentra is also contraindicated in patients with disseminated intravascular coagulation. Because Kcentra contains heparin, it is contraindicated in patients with heparin-induced thrombocytopenia (HIT). Hypersensitivity reactions to Kcentra may occur.
Can you give Kcentra and vitamin K together?
Administer vitamin K concurrently to patients receiving Kcentra. Vitamin K is administered to maintain vitamin K–dependent clotting factor levels once the effects of Kcentra have diminished.
How do you administer Praxbind?
Praxbind (2 vials of 2.5 g/50 mL) is administered intravenously as two consecutive infusions over 5 to 10 minutes each or as a bolus injection. For additional instructions for use and handling see section 6.6. None.
Is Praxbind a blood product?
Keep this leaflet. You may need to read it again. Praxbind contains the active substance idarucizumab and is a reversal agent specific for Pradaxa (dabigatran etexilate), a blood thinner medicine that blocks a substance in the body, which is involved in blood clot formation.
Do platelets reverse Plavix?
There are no specific reversal agents for clopidogrel. Since its effects are irreversible, the resultant platelet inhibition lasts for the lifespan of the platelet, ∼7–9 days.