What is the function of beta 2 microglobulin?
A function for beta 2-microglobulin as a modulator of lymphocyte surface and as a potential regulator of the immune system is proposed.
What is a high beta 2 microglobulin?
High levels of B2M in cerebrospinal fluid can mean that cancer has spread to the brain and/or spinal cord.
What is a normal beta 2 microglobulin level?
The laboratory range for normal serum beta 2 microglobulin values was 1.1 to 2.4 mg/L. Patients without documented testicular tumors had values ranging from 1.4 to 9.7 mg/L. Values for normal controls ranged from 1.7 to 2.4 mg/L.
What causes beta-2 microglobulin?
Conditions associated with an increased rate of cell production or destruction, severe infections, viral infections such as CMV (cytomegalovirus), and some conditions that activate the immune system, such as inflammatory conditions and autoimmune disorders, can cause increases in B2M levels.
What is considered high beta-2?
Values below 4 mg/l are a sign of good prognosis, whereas values over 20 mg/l area a sign of bad prognosis. However, beta-2 microglobulin blood test in not very specific because B2M level may be increased in many diseases such as infections, autoimmune diseases, inflammatory diseases, HIV or different types of cancer.
What is considered high beta 2?
Why is my beta-2 globulin high?
B2M is frequently elevated in the blood with cancers such as multiple myeloma and lymphoma and with inflammatory disorders and infections (e.g., HIV, CMV). Because B2M is increased with blood cell cancers, it may be useful as a tumor marker.
What does a high beta-2 glycoprotein mean?
A positive beta-2 glycoprotein 1 antibody test may indicate that you have antiphospholipid syndrome (APS), as they are most frequently seen with this condition. If the test is positive, it will be repeated about 12 weeks later to determine whether it is persistent or temporary.
What causes positive beta 2 glycoprotein?
What is the normal range for beta 2 glycoprotein?
Normal: β2 GPI IgG ≤ 20 SGU U/mL. β2 GPI IgM ≤ 20 SMU U/mL.
What does a high beta 2 glycoprotein mean?
What is β2 microglobulin (B2M)?
From Wikipedia, the free encyclopedia β2 microglobulin also known as B2M is a component of MHC class I molecules, MHC class I molecules have α 1, α 2, and α 3 proteins which are present on all nucleated cells (excludes red blood cells). In humans, the β 2 microglobulin protein is encoded by the B2M gene.
What is the difference between α3 and β2 microglobulin?
β 2 microglobulin lies beside the α 3 chain on the cell surface. Unlike α 3, β 2 has no transmembrane region. Directly above β 2 (that is, further away from the cell) lies the α 1 chain, which itself is next to the α 2 .
What does a low beta 2 microglobulin level indicate?
Low levels of β 2 microglobulin can indicate non-progression of HIV. Levels of β 2 microglobulin can be elevated in multiple myeloma and lymphoma, though in these cases primary amyloidosis (amyloid light chain) and secondary amyloidosis (amyloid associated protein) are more common. The normal value of β 2 microglobulin is < 2 mg/L.
What is a beta-2 microglobulin tumor marker?
A beta-2 microglobulin tumor marker test is most often given to people who have been diagnosed with certain cancers of the bone marrow or blood.