When should you check trough levels?
Trough levels are best measured when tested just before the next dose. In clinical practice, when lithium was administered in divided doses, trough levels were measured at 12 h after the last dose.
Why is a vancomycin trough drawn?
Vancomycin serum trough concentrations of 15–20 mg/L are recommended to improve penetration, increase the probability of obtaining optimal target serum concentrations and improve clinical outcomes.
When do you check vancomycin trough?
Trough levels should be checked just before the fourth dose, when steady-state levels are likely to have been achieved. More frequent monitoring may be considered in patients with fluctuating renal function. Trough levels should be higher than 10 mg/L to prevent the development of resistance.
How often are vancomycin troughs drawn?
Subsequent trough levels: o With dosage change: trough should be taken at new steady state* as described above. o Once target trough achieved: trough should be taken every 7-10 days in hemodynamically stable patients; may need more frequently if hemo-dynamically unstable, renal function changing, or patient is on …
Why are trough levels drawn?
To adequately evaluate the appropriate dosage levels of many drugs, the collection and testing of specimens for trough and peak levels is necessary. The trough level is the lowest concentration in the patient’s bloodstream, therefore, the specimen should be collected just prior to administration of the drug.
Why are peak and trough levels drawn?
What do peak and trough levels indicate? Peak and trough levels indicate drug levels in an individual’s body. A peak is the highest level of a medication in the blood, while a trough level indicates the lowest concentration.
How often are Vanco troughs drawn?
How do you collect vancomycin trough?
Vancomycin, Total – Collect the Peak specimen 1-2 hours after completion of a 60 minute IV infusion and Collect the Trough specimen just before administering next dose. Reject due: Specimens collected in SST (serum seporator tubes). Special Instructions: CANNOT be run from SST tube.
When do you check vancomycin levels?
Why does vancomycin require peak and trough levels?
Because the goal is to administer the vancomycin such that a minimally effective concentration is always maintained in the blood, measurement of blood levels is usually timed to reflect the trough and, sometimes peak, to evaluate the adequacy of dosing and clearance of the drug from the body.
When do you draw vancomycin random level?
Serum for a peak level should be drawn 1 hour after completion of dose; order VANPA / Vancomycin, Peak, Serum. 2. Serum for a trough level should be drawn no more than 30 minutes prior to next dose; order VANTA / Vancomycin, Trough, Serum.
Why do we monitor peak and trough levels?
Peak and trough levels are drawn to determine a drug’s concentration within the system. They help determine if a drug is in a toxic range or if the dosage of the medication needs to be increased. It is important to know which medications need to be monitored and what the signs and symptoms of toxicity are.
What is a trough dose of vancomycin?
Trough: just before 4th dose of a new regimen (prior to 3rd dose for dosing intervals ≥ 24 hours or changing renal function) – Trough levels should be obtained within 30 minutes before the next scheduled dose. – Weekly vancomycin levels should be obtained for long-term vancomycin use with stable renal function. Desired Levels:
When are vancomycin troughs indicated in dialysis?
Usually only vancomycin troughs are needed. Random levels may be obtained on patients with poor renal function who only receive intermittent or post-dialysis dosing. At minimum, levels should be obtained for all patients by 72 hours of therapy and at least weekly thereafter. Many patients will require more frequent monitoring.
What is the therapeutic index of vancomycin?
Vancomycin Therapeutic Drug Monitoring Vancomycin blood levels are drawn at timed intervals to measure drug levels during treatment. Vancomycin has a narrow therapeutic index, which is the ratio between the toxic and effective dose of medication.