Does zoledronic acid increase bone density?
Zoledronic acid administered as a 5 mg intravenous infusion annually increases bone mineral density in the lumbar spine and femoral neck by 6.7% and 5.1% respectively and reduces the incidence of new vertebral and hip fractures by 70% and 41% respectively in postmenopausal women with osteoporosis.
How serious is osteoporosis?
The bones that make up your spine (vertebrae) can weaken to the point that they crumple and collapse, which may result in back pain, lost height and a hunched posture. Bone fractures, particularly in the spine or hip, are the most serious complications of osteoporosis.
What is senile osteoporosis?
Senile osteoporosis has become a worldwide bone disease with the aging of the world population. It increases the risk of bone fracture and seriously affects human health. Unlike postmenopausal osteoporosis which is linked to menopause in women, senile osteoporosis is due to aging, hence, affecting both men and women.
What is the most common side effect of zoledronic acid?
Fever is the most common adverse effect associated with zoledronic acid infusion. Flu-like syndromes including fever, chills, bone pain, and/or arthralgias and myalgias have also occasionally been reported. These symptoms generally did not require treatment and resolved within 24 to 48 hours.
How safe is zoledronic acid?
Zoledronic acid had an acceptable safety profile; no adverse events were considered to be drug related. Treatment with ZA improved bone health by enhancing bone mineral density and reducing bone turnover, even in high-risk patients.
What is the safest injection for osteoporosis?
Denosumab injection (Xgeva) is used Denosumab injection is in a class of medications called RANK ligand inhibitors. It works to prevent bone loss by blocking a certain receptor in the body to decrease bone breakdown. It works to treat GCTB by blocking a certain receptor in the tumor cells which slows the tumor growth.
How does zoledronic acid make you feel?
Zoledronic acid can cause flu-like symptoms such as joint and muscle pain, fatigue, shivering and fever. These can last for a few days. Your treatment team can advise you about taking mild pain relief to help.
Is zoledronic acid a chemo drug?
Zoledronic acid (Zometa) is not cancer chemotherapy, and it will not slow or stop the spread of cancer. However, it can be used to treat bone disease in patients who have cancer. Zoledronic acid is in a class of medications called bisphosphonates.
Does zoledronic acid affect the heart?
Patients treated with zoledronic acid had a higher risk for heart failure, among other cardiovascular conditions, according to a study presented at the American Society for Bone and Mineral Research (ASBMR) 2017 Annual Meeting held September 8-11 in Denver, Colorado.
Is there stages of osteoporosis?
There are several stages of osteoporosis. The first two are more like precursors to the actual disease. In the latter two stages, you may have frequent fractures or breaks, experience pain, or even have deformities from bone loss.
Can injections help with osteoporosis?
I am no fan of needles, but I am open to the right medical treatment that may involve injections. The injection of specific drugs is one treatment option for osteoporosis. Injections are sometimes the best way to deliver drugs, particularly if one has gastrointestinal problems.
Is denosumab good for osteoporosis?
This injection is also good for those who have not been able to tolerate other osteoporosis medications. This treatment is injected by a health care professional every six months. Side effects may include muscle pain and skin irritation. Denosumab is a bone metabolism regulator. There are several possible side effects with this drug:
Who is this drug used to treat osteoporosis?
This drug is often chosen for those who have a high risk of fractures, who do not tolerate oral bisphosphonates and those who have not found success with other osteoporosis treatments. Bisphosphonates are used to treat osteoporosis by binding to the bone, slowing down the erosion of the bone. This allows the bone-building cells to work effectively.
What is the best treatment for osteoporosis?
PTH acts to increase the number of bone-building osteoblasts and has been shown to increase bone density to reduce the risk of fractures. Another treatment is the subcutaneous injection (under the skin). This includes a RANK ligand inhibitor, or monoclonal antibody, known as denosumab.