Is 6-mercaptopurine a prodrug?
Mercaptopurine is a prodrug that must first be activated to form thioguanine nucleotides (TGNs), of which 6-thioguanine triphosphate (6-TGTP) is the major active metabolite. Two of the enzymes involved in the complex pathway of these metabolites are thiopurine S-methyltransferase (TPMT) and nudix hydrolase 15 (NUDT15).
Is mercaptopurine light sensitive?
Photosensitivity has been reported with mercaptopurine therapy. Patients should be advised to protect themselves from sunlight (UV) exposure (e.g., wear protective clothing, use a broad spectrum UVA/UVB sunscreen, and wear protective lip balm when outdoors).
Is 6-MP an antimetabolite?
Purine-6-thiol is a thiol that is the tautomer of mercaptopurine. It has a role as an antineoplastic agent and an antimetabolite. It is a tautomer of a mercaptopurine.
How is 6-MP metabolized?
6-MP is oxidized to the inactive metabolite, 6-thiouric acid, by xanthine oxidase (Fig. 2). The low bioavailability of 6-MP is due to a large first pass effect as the drug is absorbed through the intestinal wall into the portal circulation and metabolized by xanthine oxidase in the intestine and liver.
Which is the activated form of 6-mercaptopurine?
6-Mercaptopurine is activated by a hypoxanthine-guanine phosphoribosyltransferase-catalyzed reaction with 5-phosphoribosylpyrophosphate (Scheme 9.34).
Can mercaptopurine be crushed?
Tablets should NOT be crushed. Consider wearing gloves and a mask when handling mercaptopurine. Always wash your hands after each dose that you give your child. If your child vomits (throws up) within 20 to 30 minutes of taking a dose, give another dose.
Can you touch mercaptopurine?
Mercaptopurine tablets or liquid should be kept in a cool, dry place away from direct sunlight or heat. You should handle these medicines with care, avoiding touching them where possible. If you are pregnant or think you could be pregnant, please discuss handling instructions with your doctor, nurse or pharmacist.
Can you cut mercaptopurine in half?
Sometimes it is necessarily to halve tablets to get the correct dose. A tablet cutter may be used for this but you should keep it only for cutting chemotherapy tablets. If your doctor decides to stop treatment with mercaptopurine or the medicine passes its expiry date, return any remaining medicine to the pharmacist.
Is 6-MP cytotoxic?
6-mercaptopurine is an active cytotoxic agent for use only under the direction of physician experienced in the administration of such agents.
Can you chew mercaptopurine?
Your doctor will calculate and adjust your dose based on your body weight, results of your blood tests, whether or not you are taking other chemotherapy medicines and your kidney and liver function. Swallow your tablets whole. Do not chew the tablets. The tablets should not be broken or crushed.
What is the half life of mercaptopurine?
Mercaptopurine
| Clinical data | |
|---|---|
| Elimination half-life | 60 to 120 min., longer for its active metabolites |
| Excretion | kidney |
| Identifiers | |
| IUPAC name 3,7-dihydropurine-6-thione |
Can you split mercaptopurine tablets?
Can mercaptopurine be cut in half?
Can mercaptopurine tablets be split?
Can I touch mercaptopurine?
Mercaptopurine tablets or liquid should be kept in a cool, dry place away from direct sunlight or heat. You should handle these medicines with care, avoiding touching them where possible.
Can I take mercaptopurine with alcohol?
Can I drink alcohol while I am taking mercaptopurine? Yes, it safe to drink alcohol while you are taking mercaptopurine, however large quantities of alcohol should be avoided.
Can you crush 6-MP?
Is mercaptopurine cytotoxic?
What is another name for mercaptopurine?
Mercaptopurine is the generic name for the trade name drug Purinethol or Purixan. In some cases, health care professionals may use the trade name Purinethol®, Purixan® or other names 6-Mercaptopurine and 6-MP when referring to the generic drug name mercaptopurine.
What does 66-mercaptopurine monohydrate react with?
6-MERCAPTOPURINE MONOHYDRATE reacts with strong oxidizing agents, strong bases and strong acids. (NTP, 1992) Use caution: Liquids with this reactive group classification have been known to react with the absorbent listed below.
What is the molecular formula of 6-mercaptopurine monohydrate?
6-Mercaptopurine monohydrate PubChem CID 2724350 Structure Find Similar Structures Chemical Safety Laboratory Chemical Safety Summary (LCSS Molecular Formula C5H4N4S.H2O or C5H6N4OS Synonyms 6-MERCAPTOPURINE MONOHYDRATE 6112-76-1 .
What is mercaptopurine?
(NTP, 1992) Mercaptopurine is a thiopurine -derivative antimetabolite with antineoplastic and immunosuppressive activities.
What happens when 6-mercaptopurine decomposes?
When heated to decomposition it emits toxic fumes of carbon monoxide, carbon dioxide, nitrogen oxides and sulfur oxides. (NTP, 1992) 6-MERCAPTOPURINE MONOHYDRATE reacts with strong oxidizing agents, strong bases and strong acids.