What is ASo4 adjuvant?
Adjuvant System 04 or AS04 is a trade name for combination of adjuvants used in various vaccine products by GlaxoSmithKline, in particular the Fendrix hepatitis B vaccine. It is also one of the ingredients of the human papillomavirus vaccine (HPV).
What is alum adjuvant?
Alum, the classical adjuvant most often used in vaccines in humans, includes a range of salts of aluminum precipitated under basic conditions, usually aluminum sulfate mixed with sodium or potassium hydroxide plus a variable amount of phosphate.
What is AS01 adjuvant?
The Adjuvant System AS01 is a liposome-based adjuvant which contains two immunostimulants, 3-O-desacyl-4′-monophosphoryl lipid A (MPL) and QS-21. 2. MPL is a non-toxic derivative of the lipopolysaccharide from Salmonella minnesota. QS-21 is a saponin fraction extracted from Quillaja saponaria Molina.
What is AS03 adjuvant?
AS03 is an Adjuvant System composed of α-tocopherol, squalene and polysorbate 80 in an oil-in-water emulsion. In various nonclinical and clinical studies, high levels of antigen-specific antibodies were obtained after administration of an AS03-adjuvanted vaccine, permitting antigen-sparing strategies.
What does ASO4 mean?
WORK LEVEL 4 (ASO4) Work Level Definitions. Duties at the fourth level require responsibility for particular function(s) within an agency. They contribute a demonstrated level of knowledge/experience and will be expected to operate with a degree of autonomy.
What is ASO4?
Definition. ASO4. Atropine Sulfate (medical antidote)
Why alum is used in vaccine?
Aluminum-containing adjuvants are vaccine ingredients that have been used in vaccines since the 1930s. Small amounts of aluminum are added to help the body build stronger immunity against the germ in the vaccine. Aluminum is one of the most common metals found in nature and is present in air, food, and water.
For what purpose alum is used?
Alum (aluminum sulfate) is a nontoxic liquid that is commonly used in water treatment plants to clarify drinking water. It’s use in lakes began in the early 1970’s and is used to reduce the amount of phosphorus in the water.
What is Matrix M adjuvant?
Matrix-M is a saponin-based adjuvant made of nanometer particles, cholesterol, and phospholipid that is developed by Novavax. 1. This compound is administered alongside vaccines to enhance biological functions: creating robust and long-lasting immune responses that may allow for dose-sparing of vaccines.
What is the purpose of the MF59 adjuvant?
MF59 is an immunologic adjuvant that uses squalene. It is Novartis’ proprietary adjuvant that is added to influenza vaccines to help stimulate the human body’s immune response through production of CD4 memory cells.
What is AS03 adjuvant made from?
The AS03 adjuvant is an oil-in-water emulsion composed of squalene, polysorbate 80 and α-tocopherol (vitamin E).
What vaccines contain AS03?
AS03 was first used in the prepandemic H5N1 vaccine Prepandrix (GlaxoSmithKline Biologicals s.a.) and was subsequently included in two influenza A(H1N1)pdm09 pandemic vaccines—Pandemrix®, GlaxoSmithKline Biologicals s.a., and Arepanrix®, GlaxoSmithKline Inc.
What is the charge of aso4?
-3
Arsenate(3-) is an arsenate ion resulting from the removal of three protons from arsenic acid….3.1Computed Properties.
Property Name | Property Value | Reference |
---|---|---|
Formal Charge | -3 | Computed by PubChem |
How much does an ASO3 get paid?
rk – Roma Mitchell House, AdelaideSalary: ASO-3 – $63,681/$67,868 p.a.12-Month Recruitment Pool Exciting opportunities exist for …
What is AsO4 charge?
arsenate (AsO43minus) Arsenate ion. Arsenate ions. arsenate(3-) arsorate.
Is AsO4 an ion?
Arsenate(3-) is an arsenate ion resulting from the removal of three protons from arsenic acid. It is a conjugate base of an arsenate(2-). Arsenate is a metabolite found in Escherichia coli (strain K12, MG1655)….8.1.1Ligands from Protein Bound 3D Structures.
PDBe Ligand Code | ART |
---|---|
PDBe Structure Code | 1TA4 |
PDBe Conformer |
Is Matrix-M adjuvant safe?
The Matrix-M adjuvant is safe for use in humans. It is an immune system-stimulating complex forming 40-nm particles derived from adjuvant-active saponins, cholesterol, and phospholipids (28) .