What is Kcentra used for?

Table of Contents

Kcentra, (Prothrombin Complex Concentrate (Human)), is indicated for the urgent reversal of acquired coagulation factor deficiency induced by Vitamin K antagonist (VKA, e.g., warfarin) therapy in adult patients with acute major bleeding.

What factors are in prothrombin complex concentrate?

Prothrombin complex concentrates (PCCs) are a source of the vitamin K-dependent coagulation factors, including factors II, VII, IX and X and proteins C and S. They are isolated from the cryoprecipitate supernatant of large plasma pools after removal of antithrombin and factor XI.

How long does Vit K take to reverse warfarin?

PCC will reverse anticoagulation within minutes of administration; FFP administration can take hours due to the volume required; vitamin K effect takes 12 to 24 hours, but administration of vitamin K is needed to counteract the long half-life of warfarin.

What drugs does Kcentra reverse?

Kcentra is a blood coagulation factor replacement product. Kcentra is used to quickly reverse the effects of a blood-thinning medicine (such as warfarin) during a major bleeding episode, or when there is a need for emergency surgery or invasive medical procedure.

Is 4-factor PCC available in the US?

The table lists 4-factor and 3-factor PCC products available in the United States. Kcentra is available as Beriplex in Canada. Bebulin (a 3-factor PCC) was discontinued in 2018 due to decreased demand for the product.

Is Kcentra a 4-factor non activated prothrombin complex concentrate?

Kcentra is a purified, heat-treated, nanofiltered, lyophilized, non-activated 4-factor prothrombin complex concentrate (4F-PCC) made from pooled human plasma. Kcentra contains all 4 vitamin–K dependent coagulation factors (II, VII, IX and X), and the antithrombotic Proteins C and S.

When do you give Kcentra?

Kcentra is indicated for the urgent reversal of acquired coagulation factor deficiency induced by vitamin K antagonist (VKA, such as warfarin) therapy in adult patients with: Need for urgent surgery or other invasive procedure or. Acute major bleeding.

Does Kcentra reverse apixaban?

There is currently no available reversal agent for apixaban. Prothrombin complex concentrate (PCC) contain clotting factors and can replace factors inhibited by anticoagulants….

Condition or disease	Intervention/treatment	Phase
Thrombosis	Drug: Kcentra Drug: Apixaban Drug: Placebo	Phase 1

Is Kcentra the same as vitamin K?

Kcentra contains all 4 Vitamin–K dependent coagulation factors (II, VII, IX and X), and the antithrombotic Proteins C and S. Unlike 3F-PCCs that are only indicated for hemophilia, Kcentra (as a 4F-PCC) has an FDA indication for urgent warfarin reversal.

Is Kcentra for Eliquis?

This is a Phase I, placebo-controlled, single site, open-label, crossover trial to evaluate the reversibility apixaban anticoagulation with Kcentra….

Condition or disease	Intervention/treatment	Phase
Thrombosis	Drug: Kcentra Drug: Apixaban Drug: Placebo	Phase 1

Is PCC and Kcentra the same?

Unlike 3F-PCCs that are only indicated for hemophilia, Kcentra (as a 4F-PCC) has an FDA indication for urgent warfarin reversal. Unlike fresh frozen plasma (FFP) administration, Kcentra replaces only those coagulation factors needed for urgent warfarin reversal.

How quickly does prothrombin complex work?

It usually reverses warfarin anticoagulation within 10-30 minutes. o Use in patients who refuse blood products and are bleeding- however it is still a blood product and therefore unacceptable to some, e.g. jehova’s witnesses.

What is the role of 4-factor prothrombin in the treatment of warfarin?

4-factor prothrombin complex concentrate is indicated for urgent reversal of vitamin K antagonists, such as warfarin, by providing the vitamin-K-dependent factors II, VII, IX, and X as well as protein C and S. Theoretically, the high concentration of these coagulation factors should assist in thrombin activation and subsequent clot formation.

What is the difference between prothrombin complex and 3F PCC?

In contrast, the 3-factor prothrombin complex concentrates (3F-PCC), which contain factors II, IX, X and only minimal amounts of factor VII, are only indicated for the prevention and control of hemorrhagic episodes in hemophilia B patients.

Is prothrombin complex effective for rapid reversal of vitamin K antagonist?

Four-factor prothrombin complex concentrate versus plasma for rapid vitamin K antagonist reversal in patients needing urgent surgical or invasive interventions: a phase 3b, open-label, non-inferiority, randomised trial. . 30. : . Potential antidotes for reversal of old and new oral anticoagulants.

Can We reverse the anticoagulant effect of rivaroxaban with four-factor prothrombin?