What is olmesartan induced enteropathy?
Abstract. Olmesartan-induced enteropathy mimics celiac disease clinically and pathologically. As in celiac disease, the pathologic findings are villous atrophy and increased intraepithelial lymphocytes. Clinical presentation of olmesartan-induced enteropathy includes diarrhea, weight loss, and nausea.
What is sprue-like syndrome?
Sprue-like enteropathy involves unexpected weight loss and severe diarrhea that can result in chronic gastrointestinal (G.I.) tract conditions including villous atrophy that can restrict the absorption of nutrients from consumed food.
Does Benicar cause celiac disease?
FRIDAY, June 22 (HealthDay News) — A new report suggests that the common blood pressure drug olmesartan (Benicar) can cause symptoms that mimic celiac disease, leading to misdiagnosis and unnecessary treatment.
What is olmesartan medoxomil used for?
Olmesartan is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly.
Does olmesartan cause loose stools?
Olmesartan, an angiotensin receptor blockade class of antihypertensive medication has recently been associated with a seronegative sprue like enteropathy. Patients typically present with diarrhea and weight loss often prompting exhaustive diagnostic workup.
What are the side effects of olmesartan?
Side effects of olmesartan
- Feeling dizzy or tired.
- Headaches, flu-like symptoms, runny or stuffy nose, cough or bronchitis.
- Pain in your back, bones or joints.
- Feeling sick (nausea) or indigestion.
- Stomach ache.
- Diarrhoea.
- Swollen feet, ankles, legs or hands (oedema)
- Urinary tract infection (UTI)
How do you treat sprue?
Treatment for Tropical Sprue includes the use of folic acid, cobalamin, and antibiotics such as tetracycline, oxytetracycline, or ampicillin. The dosage of these medications depends on the severity of the disorder as well as how the patient responds to the therapy.
Is olmesartan gluten free?
Benicar, also known as Olmesartan (generic name), can cause celiac-like enteropathies. The drug itself contains no gluten, but people can suffer severe gastrointestinal symptoms from taking the drug, so it would be best to avoid this drug.
What is the difference between olmesartan and olmesartan medoxomil?
Discontinuation of olmesartan has resulted in clinical improvement of sprue-like enteropathy symptoms in all patients. Olmesartan medoxomil is an angiotensin II receptor blocker (ARB) approved for the treatment of high blood pressure, alone or with other antihypertensive agents, and is one of eight marketed ARB drugs.
Do olmesartan side effects go away?
Some side effects of olmesartan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
How is sprue diagnosed?
Tropical sprue is a rare acquired disease, probably of infectious etiology, characterized by malabsorption and megaloblastic anemia. Diagnosis is clinical and by small-bowel biopsy. Treatment is with tetracycline and folate for 6 months.
What is a sprue in medical terms?
Sprue, nontropical: This condition results from an immune (allergic) reaction to gluten, a protein found in wheat and related grains and present in many foods that we eat. Sprue causes impaired absorption and digestion of nutrients through the small intestine. Symptoms include frequent diarrhea and weight loss.
Is olmesartan recalled 2019?
Teva Pharmaceuticals USA is recalling 181,456 bottles of olmesartan medoxomil and hydrochlorothiazide tablets, 40 mg/25 mg, after samples failed to meet dissolution specifications, according to the January 23, 2019, US Food and Drug Administration (FDA) Enforcement Report.
How is sprue treated?
Antibiotics. Tropical sprue is treated with antibiotics. This kills the bacteria overgrowth that results in this condition. Antibiotics may be given for a period of two weeks or one year.
What is olmesartan sprue-like enteropathy?
Sprue-like enteropathy associated with the angiotensin II receptor blocker (ARB) olmesartan was first described in 2012, and a number of cases have since been reported. This syndrome is characterized by severe diarrhea and sprue-like histopathologic findings in the intestine, often with increased su …
Which histopathologic findings are characteristic of olmesartan syndrome?
This syndrome is characterized by severe diarrhea and sprue-like histopathologic findings in the intestine, often with increased su … Sprue-like enteropathy associated with the angiotensin II receptor blocker (ARB) olmesartan was first described in 2012, and a number of cases have since been reported.
Can olmesartan cause weight loss and diarrhea?
Millions of people have used olmesartan. Careful consideration of patients’ medication regimens is warranted when severe and chronic diarrhea and weight loss are unexplained by other known causes of enteropathy. Greater awareness of olmesartan-induced sprue-like enteropathy, as with other drug-induced diseases,…
Does olmesartan cause villous atrophy?
Olmesartan, approved by the FDA on April 25, 2002, is one of several ARBs used for the treatment of hypertension (Table 1).10,11No other ARBs, angiotensin-converting enzyme (ACE) inhibitors, or direct renin inhibitors have been associated with the development of villous atrophy.