What is the pathophysiology of dengue fever?
Pathophysiology Primary manifestations of disease include capillary leak syndrome (plasma leakage due to DHF-specific endothelial cell dysfunction), thrombocytopenia (seen in all types of DENV infection, but extreme in DHF), hemorrhagic tendencies, and leukopenia.
What is the key pathologic feature of dengue hemorrhagic fever?
The two fundamental pathological attributes in DHF are plasma leakage and intrinsic coagulopathy. The balance of hydrostatic and oncotic pressures is important in plasma leakage.
Why does dengue cause hemorrhagic fever?
This is called severe dengue, dengue hemorrhagic fever or dengue shock syndrome. Severe dengue happens when your blood vessels become damaged and leaky. And the number of clot-forming cells (platelets) in your bloodstream drops. This can lead to shock, internal bleeding, organ failure and even death.
What is the pathogen and vector for dengue hemorrhagic fever?
Dengue is a viral infection transmitted to humans through the bite of infected mosquitoes. The primary vectors that transmit the disease are Aedes aegypti mosquitoes and, to a lesser extent, Ae. albopictus. The virus responsible for causing dengue, is called dengue virus (DENV).
What is the difference of dengue fever and dengue hemorrhagic fever?
DHF is a more severe form of dengue. Initial symptoms are the same as dengue but are followed by bleeding problems such as easy bruising, skin hemorrhages, bleeding from the nose or gums, and possible bleeding of the internal organs. DHF is very rare.
What are the main organs involved in dengue hemorrhagic fever?
The liver as a target of immune-mediated mechanisms in dengue fatal cases. The liver is considered as an important target for DENV infection and is the most common organ to be involved in the disease.
What is difference between dengue fever and hemorrhagic fever?
Despite the name, the critical feature that distinguishes DHF from dengue fever is not hemorrhaging, but rather plasma leakage resulting from increased vascular permeability. EVALUATE the patient’s heart rate, capillary refill, skin color and temperature, peripheral pulse volume, pulse pressure, and blood pressure.
What is the phase that occurs with dengue hemorrhagic fever?
Dengue begins abruptly after a typical incubation period of 5–7 days, and the course follows 3 phases: febrile, critical, and convalescent.
What is the difference between dengue hemorrhagic fever and dengue fever?
What are types of pathophysiology?
There are three main subtypes of pathology: anatomical pathology, clinical pathology, and molecular pathology.
WHO dengue hemorrhagic fever criteria?
The WHO criteria fordengue hemorrhagic fever are fever (2-7 days in duration or biphasic), minor or major hemorrhagic manifestations including a positive tourniquet test, thrombocytopenia (≤100,000/µL), and objective evidence of increased capillary permeability (hematocrit increased by ≥ 20%), pleural effusion or …
What is dengue fever PPT?
INTRODUCTION 3 Dengue fever is an acute infectious viral disease, also known as breakbone fever. It is a arthropod-borne (arboviral ) illness in human . It is caused by infection with 1 of the 4 serotypes of dengue virus (DENV1,2,3,4), which is a Flavivirus (a genus of single-stranded nonsegmented RNA viruses).
What is a pathophysiology process?
Definition. Pathophysiology (consisting of the Greek origin words “pathos” = suffering; “physis” = nature, origin; and “logos” = “the study of”) refers to the study of abnormal changes in body functions that are the causes, consequences, or concomitants of disease processes.
What is dengue hemorrhagic fever?
Dengue is the most common and important mosquito-borne viral infection and can manifest as Dengue Fever (DF), which is often a self-limiting febrile illness or less commonly dengue hemorrhagic fever (DHF).
What is the pathophysiology of dengue shock syndrome (Dengue shock syndrome)?
The major pathophysiologic hallmarks that distinguish DHF from DF and other diseases are increased vascular permeability leading to plasma leakage and circulatory collapse (Dengue Shock Syndrome/DSS).
How many people are affected by dengue each year?
An estimated 2.5 billion people are at risk of dengue infection, and of the 100 million cases of dengue fever per year, up to 500,000 develop dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS), the life-threatening forms of the infection. The large majority of DHF/DSS occurs as the result …