What is thiazole used for?
Commercial significant thiazoles include mainly dyes and fungicides. Thifluzamide, Tricyclazole, and Thiabendazole are marketed for control of various agricultural pests. Another widely used thiazole derivative is the non-steroidal anti-inflammatory drug Meloxicam.
Is thiazole electron rich?
Thiazole is a π-electron-excessive heterocycle. The electronegativity of the N-atom at the 3-position makes C(2) partially electropositive and therefore susceptible to nucleophilic attack. In contrast, electrophilic substitution of thiazoles preferentially takes place at the electron-rich C(5) position.
What is thiazole structure?
C3H3NSThiazole / Formula
Is thiazole the most basic?
Chemical Reactivity Thiazole is more basic than oxazole but less basic than pyridine and forms stable picrate salts. Its chemical reactivity is very similar to thiophene and pyridine due to the presence of thiophene-type sulfur at position 1 and pyridine-type nitrogen at position 3 of the thiazole ring.
What is thiazole made of?
thiazole, any of a class of organic compounds of the heterocyclic series characterized by a ring structure composed of three carbon atoms, one nitrogen atom, and one sulfur atom.
How is thiazole prepared?
The 2,5-substituted thiazole 34 is prepared from aldehyde 33, amine 32, and element sulfur using Cu-catalyzed aerobic oxidative reactions (18OL2632). Condensation of amine 32 and aldehyde 33 followed by tautomerization gives enamine 36, which reacts with an electrophilic element sulfur to form 37.
Why is thiazole basic?
Is thiazole ring hydrophilic?
The structure–activity relationship studies revealed that the presence of a nonpolar, hydrophobic moiety at position 2 of thiazole and the ethylidenehydrazine-1-carboximidamide head group at position 5 are beneficial for the antibacterial activity of these compounds.
Why is thiazole aromatic?
The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current.