What is Tubulolobular carcinoma?
A tubulolobular carcinoma (TLC) of the breast is considered a subtype of breast cancer that features of both invasive lobular carcinoma and tubular carcinoma of the breast. It therefore exhibits features of both ductal and lobular differentiation.
What is Ki67 breast cancer?
Ki67 is a nuclear antigen that is an excellent marker of active cell proliferation in the normal and tumor cell populations (1). It has been proposed as a useful clinical marker for breast cancer subtype classification, prognosis, and prediction of therapeutic response (2–4).
How common is ductal carcinoma in situ?
About 1 in 5 new breast cancers will be ductal carcinoma in situ (DCIS). Nearly all women with this early stage of breast cancer can be cured. DCIS is also called intraductal carcinoma or stage 0 breast cancer.
What does tumor cells positive for GATA3 mean?
Gene expression profiling has shown that GATA-3 is highly expressed in the Luminal A subtype of breast cancer. A recent study found GATA-3 to be associated with favorable breast cancer pathologic features, including negative lymph node and positive estrogen receptor (ER) status.
What does CK7 negative mean?
For the CK7 negative group, no tumor cells yielded positive IHC staining results for CK7. For the CK7 positive group, diffuse or focal CK7 positive tumor cells were present in tumor tissue. The diffuse distribution of CK7 positive tumor cells was often present in poorly differentiated CRCs.
Does tubular carcinoma recur?
The survival rate for tubular carcinoma is approximately 97 percent at the 10-year mark. The survival rate is better for tubular carcinoma alone than when it’s mixed with other subtypes. One study shows a recurrence rate of 6.9 percent.
Is tubular breast rare?
Tubular breast cancer is a rare type of invasive breast cancer. It’s most common in women over 50, although you can get it at any age.
Can DCIS come back after mastectomy?
Recurrence is rare following mastectomy for DCIS. Nevertheless, there remains a need to follow patients for in-breast, nodal, or contralateral breast events, which can occur long after the index DCIS has been treated.
What is GATA3 a marker for?
GATA3 is a useful marker in characterization not only mammary and urothelial but also for renal and germ cell tumors, mesotheliomas, and paragangliomas. The multiple specificities of GATA3 should be taken into account when using this marker to detect metastatic mammary or urothelial carcinomas.
What does it mean when a tumor is positive for CK7?
Is tubular carcinoma hereditary?
Some risk factors for tubular carcinoma may include: genetics and family history. radiation to your face or chest to treat another type of cancer before the age of 30.
Does tubular carcinoma metastasis?
[1] Because of its nonaggressive, histologic appearance, its low propensity to recur locally, spread to axillary lymph nodes, and metastasize distantly, pure tubular carcinoma carries a favorable prognosis. [2][3] Its diagnosis is established based on histopathological examination of the surgical specimen.
Can I breastfeed with tubular breasts?
It is certainly possible to breastfeed with hypoplastic or tuberous breasts. Breastfeeding depends on the milk-production tissue in your breasts, and there might be sufficient tissue to produce enough milk.